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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2001 Volume 7 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2001 Volume 7 Issue 2

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Article

Enhancement of the antiproliferative function of p53 by phosphorylation at serine 20: an inference from site-directed mutagenesis studies

  • Authors:
    • James R. Jabbur
    • Peng Huang
    • Wei Zhang

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA
  • Pages: 163-168
    |
    Published online on: February 1, 2001
       https://doi.org/10.3892/ijmm.7.2.163
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Abstract

Recent studies have shown that Ser20 of p53 is phosphorylated in vivo in response to DNA damage caused by ionizing radiation (IR) or ultraviolet radiation (UV), treatments that also result in the induction of p21WAF1/Cip1 (p21) expression. We hypothesized that Ser20 phosphorylation enhances the transactivation function of p53. To test this, we generated two p53 mutants, changing the Ser residue to either Ala, an uncharged form that may mimic unphosphorylated p53, or to Asp, a negatively charged form that may mimic constitutively phosphorylated p53. p53-null cells transfected with the Ser20 phosphorylation-mimicking mutant p53Asp20 demonstrated heightened p21 expression and reduced cell proliferation relative to wild-type p53-transfected cells. Moreover, p53Asp20 exhibited reduced capacity to interact with the Mdm-2 protein in vitro. This abridged interaction had no effect, however, on p53 protein stability. These results suggest that the phosphorylation of p53 at Ser20 is an important mechanism in the activation of the p53/p21 cell-growth inhibitory pathways in response to DNA damage by IR and UV.

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Copy and paste a formatted citation
Spandidos Publications style
Jabbur JR, Huang P and Zhang W: Enhancement of the antiproliferative function of p53 by phosphorylation at serine 20: an inference from site-directed mutagenesis studies. Int J Mol Med 7: 163-168, 2001.
APA
Jabbur, J.R., Huang, P., & Zhang, W. (2001). Enhancement of the antiproliferative function of p53 by phosphorylation at serine 20: an inference from site-directed mutagenesis studies. International Journal of Molecular Medicine, 7, 163-168. https://doi.org/10.3892/ijmm.7.2.163
MLA
Jabbur, J. R., Huang, P., Zhang, W."Enhancement of the antiproliferative function of p53 by phosphorylation at serine 20: an inference from site-directed mutagenesis studies". International Journal of Molecular Medicine 7.2 (2001): 163-168.
Chicago
Jabbur, J. R., Huang, P., Zhang, W."Enhancement of the antiproliferative function of p53 by phosphorylation at serine 20: an inference from site-directed mutagenesis studies". International Journal of Molecular Medicine 7, no. 2 (2001): 163-168. https://doi.org/10.3892/ijmm.7.2.163
Copy and paste a formatted citation
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Spandidos Publications style
Jabbur JR, Huang P and Zhang W: Enhancement of the antiproliferative function of p53 by phosphorylation at serine 20: an inference from site-directed mutagenesis studies. Int J Mol Med 7: 163-168, 2001.
APA
Jabbur, J.R., Huang, P., & Zhang, W. (2001). Enhancement of the antiproliferative function of p53 by phosphorylation at serine 20: an inference from site-directed mutagenesis studies. International Journal of Molecular Medicine, 7, 163-168. https://doi.org/10.3892/ijmm.7.2.163
MLA
Jabbur, J. R., Huang, P., Zhang, W."Enhancement of the antiproliferative function of p53 by phosphorylation at serine 20: an inference from site-directed mutagenesis studies". International Journal of Molecular Medicine 7.2 (2001): 163-168.
Chicago
Jabbur, J. R., Huang, P., Zhang, W."Enhancement of the antiproliferative function of p53 by phosphorylation at serine 20: an inference from site-directed mutagenesis studies". International Journal of Molecular Medicine 7, no. 2 (2001): 163-168. https://doi.org/10.3892/ijmm.7.2.163
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