Development of anorexia in concanavalin A-induced hepatitis in mice

  • Authors:
    • Toshihiro Okamoto
    • Susumu Okabe
  • View Affiliations

  • Published online on: February 1, 2001     https://doi.org/10.3892/ijmm.7.2.169
  • Pages: 169-172
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Abstract

Anorexia that develops in chronic hepatitis is associated with cytokine expression in the brain. Treatment of mice with concanavalin A (12.5 mg/kg, i.v.) elevated the plasma alanine aminotransferase activity at 8.5 h after treatment. Tumor necrosis factor-α (TNF-α) and interleukin-1β mRNA expression was induced at 6 and 24 h after concanavalin A treatment in both the liver and brain. Treatment of mice with concanavalin A reduced the body weight at 24 h after treatment and this decreased body weight was accompanied by a decreased food intake. Glycyrrhizin (200 mg/kg, i.p.) inhibited the concanavalin A-induced elevation of plasma alanine aminotransferase activity, however, it did not inhibit the concanavalin A-induced decreased body weight. The present results indicate that treatment of mice with concanavalin A caused the development of anorexia and that this anorexia might develop independently of the induction of hepatitis.

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February 2001
Volume 7 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Okamoto T and Okamoto T: Development of anorexia in concanavalin A-induced hepatitis in mice. Int J Mol Med 7: 169-172, 2001
APA
Okamoto, T., & Okamoto, T. (2001). Development of anorexia in concanavalin A-induced hepatitis in mice. International Journal of Molecular Medicine, 7, 169-172. https://doi.org/10.3892/ijmm.7.2.169
MLA
Okamoto, T., Okabe, S."Development of anorexia in concanavalin A-induced hepatitis in mice". International Journal of Molecular Medicine 7.2 (2001): 169-172.
Chicago
Okamoto, T., Okabe, S."Development of anorexia in concanavalin A-induced hepatitis in mice". International Journal of Molecular Medicine 7, no. 2 (2001): 169-172. https://doi.org/10.3892/ijmm.7.2.169