Inhibition of anti-Fas antibody-induced mice hepatitis by furocoumarin derivatives

  • Authors:
    • Toshihiro Okamoto
    • Shinichi Yoshida
    • Tadashi Kobayashi
    • Susumu Okabe
  • View Affiliations

  • Published online on: February 1, 2001     https://doi.org/10.3892/ijmm.7.2.177
  • Pages: 177-180
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Abstract

The effects of imperatorin and its synthetic derivative, Y355, on anti-Fas antibody-induced mice hepatitis were studied. Pretreatment of mice by intraperitoneal administration of imperatorine or Y355 at 30 mg/kg inhibited more than 80% of the anti-Fas antibody (150 μg/kg, i.v.)-induced elevation of plasma alanine aminotransferase activity. Furthermore, oral administration of imperatorin or Y355 at 100 mg/kg also had an inhibitory effect on anti-Fas antibody-induced hepatitis. Both compounds inhibited anti-Fas antibody (250 μg/kg)-induced caspase-1 and caspase-3 activities. The present results showed the inhibition of anti-Fas antibody-induced hepatitis by imperatorin and Y355, which might be a result of inhibition of caspase activities.

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February 2001
Volume 7 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Okamoto T, Yoshida S, Kobayashi T and Okabe S: Inhibition of anti-Fas antibody-induced mice hepatitis by furocoumarin derivatives. Int J Mol Med 7: 177-180, 2001.
APA
Okamoto, T., Yoshida, S., Kobayashi, T., & Okabe, S. (2001). Inhibition of anti-Fas antibody-induced mice hepatitis by furocoumarin derivatives. International Journal of Molecular Medicine, 7, 177-180. https://doi.org/10.3892/ijmm.7.2.177
MLA
Okamoto, T., Yoshida, S., Kobayashi, T., Okabe, S."Inhibition of anti-Fas antibody-induced mice hepatitis by furocoumarin derivatives". International Journal of Molecular Medicine 7.2 (2001): 177-180.
Chicago
Okamoto, T., Yoshida, S., Kobayashi, T., Okabe, S."Inhibition of anti-Fas antibody-induced mice hepatitis by furocoumarin derivatives". International Journal of Molecular Medicine 7, no. 2 (2001): 177-180. https://doi.org/10.3892/ijmm.7.2.177