Sodium 1-monolinolenin isolated from Italian ryegrass (Lolium multiflorum Lam) induces apoptosis in human lymphoid leukemia Molt 4B cells

  • Authors:
    • M. Kyohkon
    • T. Komiya
    • S. Ohwaki
    • H. Katsuzaki
    • K. Imai
    • R. Nishide
    • H. Ikeda
    • H. Hibasami
  • View Affiliations

  • Published online on: March 1, 2001     https://doi.org/10.3892/ijmm.7.3.265
  • Pages: 265-268
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Abstract

The exposure of human lymphoid leukemia Molt 4B cells to sodium 1-monolinolenin (SML) which was isolated from the leaves of Italian ryegrass (Lolium multiflorum Lam) and identified by Mass, and 1H- and 13C-NMR, led to both growth inhibition and induction of programmed cell death (apoptosis). Morphological change showing apoptotic bodies was observed in the Molt 4B cells treated with SML. The fragmentation by SML of DNA to oligonucleosomal-sized fragments, that is a characteristic of apoptosis, was observed to be both concentration- and time-dependent. These findings suggest that growth inhibition by SML of Molt 4B cells results from the induction of apoptosis in the cells.

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March 2001
Volume 7 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kyohkon M, Komiya T, Ohwaki S, Katsuzaki H, Imai K, Nishide R, Ikeda H and Hibasami H: Sodium 1-monolinolenin isolated from Italian ryegrass (Lolium multiflorum Lam) induces apoptosis in human lymphoid leukemia Molt 4B cells. Int J Mol Med 7: 265-268, 2001.
APA
Kyohkon, M., Komiya, T., Ohwaki, S., Katsuzaki, H., Imai, K., Nishide, R. ... Hibasami, H. (2001). Sodium 1-monolinolenin isolated from Italian ryegrass (Lolium multiflorum Lam) induces apoptosis in human lymphoid leukemia Molt 4B cells. International Journal of Molecular Medicine, 7, 265-268. https://doi.org/10.3892/ijmm.7.3.265
MLA
Kyohkon, M., Komiya, T., Ohwaki, S., Katsuzaki, H., Imai, K., Nishide, R., Ikeda, H., Hibasami, H."Sodium 1-monolinolenin isolated from Italian ryegrass (Lolium multiflorum Lam) induces apoptosis in human lymphoid leukemia Molt 4B cells". International Journal of Molecular Medicine 7.3 (2001): 265-268.
Chicago
Kyohkon, M., Komiya, T., Ohwaki, S., Katsuzaki, H., Imai, K., Nishide, R., Ikeda, H., Hibasami, H."Sodium 1-monolinolenin isolated from Italian ryegrass (Lolium multiflorum Lam) induces apoptosis in human lymphoid leukemia Molt 4B cells". International Journal of Molecular Medicine 7, no. 3 (2001): 265-268. https://doi.org/10.3892/ijmm.7.3.265