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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
March 2001 Volume 7 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March 2001 Volume 7 Issue 3

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Article

Tumor-induced insufficiency in T cell activity and hyperproduction of interleukin-2 in rat giant hepatomas

  • Authors:
    • H. Ben-Hur
    • P. Gurevich
    • S. Calmanovich
    • S. Gershon
    • I. Zusman

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel
  • Pages: 269-272
    |
    Published online on: March 1, 2001
       https://doi.org/10.3892/ijmm.7.3.269
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Abstract

The roles of lymphoid elements and apoptosis-related proteins in the development of extremely large hepatomas were studied in rats. Hepatoma cells were inoculated subcutaneously into 6-week-old rats, and 4 months later the quantities of T and B cells, macrophages, and cells positive for Fas, Fas ligand (FasL) and interleukin-2 (IL-2) were immunochemically evaluated in tumors. Grafting of hepatoma cells caused the development of giant tumors that could reach one-third of the rat's body weight. Within the hepatomas, almost all CD8+ T cells were destroyed as they passed from the tumoral stroma into the parenchyma and came in contact with tumor epithelial cells. This could be the consequence of IL-2 production, since about 90% of tumor cells were CD25+. The tumoral mass increased despite the significant increase in tumor necrosis. Cells with Ki67 or in mitosis, and cells positive for Fas and FasL were found only among tumor epithelial cells that were necrotic and never among viable cells. We suggest that progress in tumorigenesis is facilitated by inhibition of T helper cells, and the extensive death of T killer cells is caused by the high levels of the tumor produced IL-2.

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Copy and paste a formatted citation
Spandidos Publications style
Ben-Hur H, Gurevich P, Calmanovich S, Gershon S and Zusman I: Tumor-induced insufficiency in T cell activity and hyperproduction of interleukin-2 in rat giant hepatomas. Int J Mol Med 7: 269-272, 2001.
APA
Ben-Hur, H., Gurevich, P., Calmanovich, S., Gershon, S., & Zusman, I. (2001). Tumor-induced insufficiency in T cell activity and hyperproduction of interleukin-2 in rat giant hepatomas. International Journal of Molecular Medicine, 7, 269-272. https://doi.org/10.3892/ijmm.7.3.269
MLA
Ben-Hur, H., Gurevich, P., Calmanovich, S., Gershon, S., Zusman, I."Tumor-induced insufficiency in T cell activity and hyperproduction of interleukin-2 in rat giant hepatomas". International Journal of Molecular Medicine 7.3 (2001): 269-272.
Chicago
Ben-Hur, H., Gurevich, P., Calmanovich, S., Gershon, S., Zusman, I."Tumor-induced insufficiency in T cell activity and hyperproduction of interleukin-2 in rat giant hepatomas". International Journal of Molecular Medicine 7, no. 3 (2001): 269-272. https://doi.org/10.3892/ijmm.7.3.269
Copy and paste a formatted citation
x
Spandidos Publications style
Ben-Hur H, Gurevich P, Calmanovich S, Gershon S and Zusman I: Tumor-induced insufficiency in T cell activity and hyperproduction of interleukin-2 in rat giant hepatomas. Int J Mol Med 7: 269-272, 2001.
APA
Ben-Hur, H., Gurevich, P., Calmanovich, S., Gershon, S., & Zusman, I. (2001). Tumor-induced insufficiency in T cell activity and hyperproduction of interleukin-2 in rat giant hepatomas. International Journal of Molecular Medicine, 7, 269-272. https://doi.org/10.3892/ijmm.7.3.269
MLA
Ben-Hur, H., Gurevich, P., Calmanovich, S., Gershon, S., Zusman, I."Tumor-induced insufficiency in T cell activity and hyperproduction of interleukin-2 in rat giant hepatomas". International Journal of Molecular Medicine 7.3 (2001): 269-272.
Chicago
Ben-Hur, H., Gurevich, P., Calmanovich, S., Gershon, S., Zusman, I."Tumor-induced insufficiency in T cell activity and hyperproduction of interleukin-2 in rat giant hepatomas". International Journal of Molecular Medicine 7, no. 3 (2001): 269-272. https://doi.org/10.3892/ijmm.7.3.269
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