Expression of CD44 splice variants in spontaneous murine tumors

  • Authors:
    • Mariano Sanchez Lockhart
    • Paula Cabrera
    • Miriam Diament
    • Elida Alvarez
    • Danka Klein
    • Silvia E. Hajos
  • View Affiliations

  • Published online on: May 1, 2001     https://doi.org/10.3892/ijmm.7.5.557
  • Pages: 557-562
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Abstract

CD44 is a widely distributed set of cell surface glycoproteins expressed in several types of cells and tissues, implicated in cell-cell and cell-substrate interactions. This molecule plays a major role in cell differentiation, development and activation and has also been described as a potential marker of malignancy and metastasis. In the present study we investigated by RT-PCR followed by exon specific amplification the expression of CD44 splice variants in four different murine tumors as well as in the invaded organs in order to correlate the expression of CD44 variants with potential tumor invasiveness and their implications for growth. Our data showed deregulation in the expression of CD44 isoforms but no discernible correlation in isoform expression pattern. However, in all tumors studied isoforms presented by the primary tumor were detected in the invaded organs before metastasis could be demonstrated by histopathological analysis.

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May 2001
Volume 7 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Sanchez Lockhart M, Cabrera P, Diament M, Alvarez E, Klein D and Hajos SE: Expression of CD44 splice variants in spontaneous murine tumors. Int J Mol Med 7: 557-562, 2001
APA
Sanchez Lockhart, M., Cabrera, P., Diament, M., Alvarez, E., Klein, D., & Hajos, S.E. (2001). Expression of CD44 splice variants in spontaneous murine tumors. International Journal of Molecular Medicine, 7, 557-562. https://doi.org/10.3892/ijmm.7.5.557
MLA
Sanchez Lockhart, M., Cabrera, P., Diament, M., Alvarez, E., Klein, D., Hajos, S. E."Expression of CD44 splice variants in spontaneous murine tumors". International Journal of Molecular Medicine 7.5 (2001): 557-562.
Chicago
Sanchez Lockhart, M., Cabrera, P., Diament, M., Alvarez, E., Klein, D., Hajos, S. E."Expression of CD44 splice variants in spontaneous murine tumors". International Journal of Molecular Medicine 7, no. 5 (2001): 557-562. https://doi.org/10.3892/ijmm.7.5.557