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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
June 2001 Volume 7 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2001 Volume 7 Issue 6

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Article

Radiation-induced apoptosis of human peripheral T cells: Analyses with cDNA expression arrays and mitochondrial membrane potential assay

  • Authors:
    • Y. Ogawa
    • A. Nishioka
    • T. Kobayashi
    • S. Kariya
    • S. Hamasato
    • T. Saibara
    • H. Seguchi
    • S. Yoshida

  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Kochi Medical School, Oko-cho, Nankoku-shi, Kochi-Prefecture 783-8505, Japan
  • Pages: 603-607
    |
    Published online on: June 1, 2001
       https://doi.org/10.3892/ijmm.7.6.603
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Abstract

We examined sequential changes in post-irradiated peripheral blood T cells taken from normal volunteers, by using targeted Atlas cDNA Expression Arrays and mitochondrial membrane potential assay. At 1 and 3 hours after 5 Gy irradiation, changes of gene expression were examined by targeted Atlas cDNA Expression Arrays using Apoptosis Array. The Atlas Human Apoptosis Array includes 205 key genes that are known to control apoptosis, including extracellular and cytoplasmic effectors. Concerning Fas, no significant changes of spot intensities were identified between irradiated T cells and non-irradiated ones at both 1 h and 3 h after 5 Gy irradiation. Caspase families, including caspases 9 and 3 also showed no changes between these two groups. An apoptosis regulator bclw showed a remarkable decrease in irradiated T cells. These results suggested that irradiation induced direct apoptosis of T cells by changing the membrane potential of mitochondria. Using a CCD camera-equipped fluorescence microscope and MitoCapture, a mitochondrial membrane potential indicator, we demonstrated 5 Gy radiation induced loss of membrane potential, i.e., an early stage of apoptosis, in human peripheral blood T cells at 10 hours after irradiation.

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Copy and paste a formatted citation
Spandidos Publications style
Ogawa Y, Nishioka A, Kobayashi T, Kariya S, Hamasato S, Saibara T, Seguchi H and Yoshida S: Radiation-induced apoptosis of human peripheral T cells: Analyses with cDNA expression arrays and mitochondrial membrane potential assay. Int J Mol Med 7: 603-607, 2001.
APA
Ogawa, Y., Nishioka, A., Kobayashi, T., Kariya, S., Hamasato, S., Saibara, T. ... Yoshida, S. (2001). Radiation-induced apoptosis of human peripheral T cells: Analyses with cDNA expression arrays and mitochondrial membrane potential assay. International Journal of Molecular Medicine, 7, 603-607. https://doi.org/10.3892/ijmm.7.6.603
MLA
Ogawa, Y., Nishioka, A., Kobayashi, T., Kariya, S., Hamasato, S., Saibara, T., Seguchi, H., Yoshida, S."Radiation-induced apoptosis of human peripheral T cells: Analyses with cDNA expression arrays and mitochondrial membrane potential assay". International Journal of Molecular Medicine 7.6 (2001): 603-607.
Chicago
Ogawa, Y., Nishioka, A., Kobayashi, T., Kariya, S., Hamasato, S., Saibara, T., Seguchi, H., Yoshida, S."Radiation-induced apoptosis of human peripheral T cells: Analyses with cDNA expression arrays and mitochondrial membrane potential assay". International Journal of Molecular Medicine 7, no. 6 (2001): 603-607. https://doi.org/10.3892/ijmm.7.6.603
Copy and paste a formatted citation
x
Spandidos Publications style
Ogawa Y, Nishioka A, Kobayashi T, Kariya S, Hamasato S, Saibara T, Seguchi H and Yoshida S: Radiation-induced apoptosis of human peripheral T cells: Analyses with cDNA expression arrays and mitochondrial membrane potential assay. Int J Mol Med 7: 603-607, 2001.
APA
Ogawa, Y., Nishioka, A., Kobayashi, T., Kariya, S., Hamasato, S., Saibara, T. ... Yoshida, S. (2001). Radiation-induced apoptosis of human peripheral T cells: Analyses with cDNA expression arrays and mitochondrial membrane potential assay. International Journal of Molecular Medicine, 7, 603-607. https://doi.org/10.3892/ijmm.7.6.603
MLA
Ogawa, Y., Nishioka, A., Kobayashi, T., Kariya, S., Hamasato, S., Saibara, T., Seguchi, H., Yoshida, S."Radiation-induced apoptosis of human peripheral T cells: Analyses with cDNA expression arrays and mitochondrial membrane potential assay". International Journal of Molecular Medicine 7.6 (2001): 603-607.
Chicago
Ogawa, Y., Nishioka, A., Kobayashi, T., Kariya, S., Hamasato, S., Saibara, T., Seguchi, H., Yoshida, S."Radiation-induced apoptosis of human peripheral T cells: Analyses with cDNA expression arrays and mitochondrial membrane potential assay". International Journal of Molecular Medicine 7, no. 6 (2001): 603-607. https://doi.org/10.3892/ijmm.7.6.603
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