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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
June 2001 Volume 7 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2001 Volume 7 Issue 6

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Article

Defect of lck in a patient with common variable immunodeficiency

  • Authors:
    • Takuya Sawabe
    • Takahiko Horiuchi
    • Minoru Nakamura
    • Hiroshi Tsukamoto
    • Kumiko Nakahara
    • Shin-Ichi Harashima
    • Tanji Tsuchiya
    • Shuji Nakano

  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan
  • Pages: 609-614
    |
    Published online on: June 1, 2001
       https://doi.org/10.3892/ijmm.7.6.609
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Abstract

Common variable immunodeficiency (CVID) is a congenital immunological disorder characterized by defective antibody production with normal count of peripheral B lymphocytes. The basic immunologic defects that leads to CVID are still unknown, however, a proportion of CVID is suggested to be caused by decreased CD4+ helper T cell activity. In addition, recent reports indicate that a defect of T cell receptor (TCR)-associated signaling molecules results in congenital immune deficiency in human. In the present study, we investigated lck, a signaling molecule downstream of TCR, in a patient with CVID plus CD4 lymphopenia, and found an aberrantly spliced lck transcript lacking the entire exon 7 associated with the decrease in the expression of lck protein. An identical splicing abnormality has been previously demonstrated in a case of severe combined immunodeficiency with selective CD4 lymphopenia, although the case showed almost complete loss of the expression of lck protein. Considering these findings, the aberrant splicing of lck gene is suggested to be correlated, at least with a subset of congenital immunodeficiency plus CD4 lymphopenia.

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Copy and paste a formatted citation
Spandidos Publications style
Sawabe T, Horiuchi T, Nakamura M, Tsukamoto H, Nakahara K, Harashima S, Tsuchiya T and Nakano S: Defect of lck in a patient with common variable immunodeficiency. Int J Mol Med 7: 609-614, 2001.
APA
Sawabe, T., Horiuchi, T., Nakamura, M., Tsukamoto, H., Nakahara, K., Harashima, S. ... Nakano, S. (2001). Defect of lck in a patient with common variable immunodeficiency. International Journal of Molecular Medicine, 7, 609-614. https://doi.org/10.3892/ijmm.7.6.609
MLA
Sawabe, T., Horiuchi, T., Nakamura, M., Tsukamoto, H., Nakahara, K., Harashima, S., Tsuchiya, T., Nakano, S."Defect of lck in a patient with common variable immunodeficiency". International Journal of Molecular Medicine 7.6 (2001): 609-614.
Chicago
Sawabe, T., Horiuchi, T., Nakamura, M., Tsukamoto, H., Nakahara, K., Harashima, S., Tsuchiya, T., Nakano, S."Defect of lck in a patient with common variable immunodeficiency". International Journal of Molecular Medicine 7, no. 6 (2001): 609-614. https://doi.org/10.3892/ijmm.7.6.609
Copy and paste a formatted citation
x
Spandidos Publications style
Sawabe T, Horiuchi T, Nakamura M, Tsukamoto H, Nakahara K, Harashima S, Tsuchiya T and Nakano S: Defect of lck in a patient with common variable immunodeficiency. Int J Mol Med 7: 609-614, 2001.
APA
Sawabe, T., Horiuchi, T., Nakamura, M., Tsukamoto, H., Nakahara, K., Harashima, S. ... Nakano, S. (2001). Defect of lck in a patient with common variable immunodeficiency. International Journal of Molecular Medicine, 7, 609-614. https://doi.org/10.3892/ijmm.7.6.609
MLA
Sawabe, T., Horiuchi, T., Nakamura, M., Tsukamoto, H., Nakahara, K., Harashima, S., Tsuchiya, T., Nakano, S."Defect of lck in a patient with common variable immunodeficiency". International Journal of Molecular Medicine 7.6 (2001): 609-614.
Chicago
Sawabe, T., Horiuchi, T., Nakamura, M., Tsukamoto, H., Nakahara, K., Harashima, S., Tsuchiya, T., Nakano, S."Defect of lck in a patient with common variable immunodeficiency". International Journal of Molecular Medicine 7, no. 6 (2001): 609-614. https://doi.org/10.3892/ijmm.7.6.609
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