Glut-1 expression in dysplastic and regenerative lesions of the colon

  • Authors:
    • F. Fogt
    • A. Wellmann
    • S. J. Urbanski
    • A. Noffsinger
    • C. Poremba
    • R. L. Zimmerman
    • N. Alsaigh
  • View Affiliations

  • Published online on: June 1, 2001     https://doi.org/10.3892/ijmm.7.6.615
  • Pages: 615-619
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Abstract

Monosaccaride transporter proteins are responsible for transmembrane transport of monosaccarides into cells. Glucose transporter protein 1 (Glut-1) is most prevalent in the cell membranes of erythrocytes and facilitates transport of glucose in tissues with barrier functions, i.e. blood brain barrier. Expression of Glut-1 in malignant tumors is increased due to increased metabolic need of the proliferating cell populations. In colorectal adenomas and carcinomas, membranous expression of Glut-1 has been associated with higher grade of tumors and decreased survival time. We studied the expression of Glut-1 in dysplastic proliferations of the colon which included sporadic adenomas and dysplasia associated lesions (DALM) in patients with ulcerative colitis and reactive/regenerative proliferations of the colon, including non-dysplastic chronic colitis, acute colitis and ischemia. Two patterns of Glut-1 expression were detected. Most adenomas and DALMs showed at least focal membranous expression of Glut-1. In addition a second staining pattern was recognized which consisted of prominent supranuclear dots. This pattern of staining was not only seen in adenomas and DALM but also in non-dysplastic areas immediately surrounding sporadic adenomas, in regenerative chronic colitis and in areas surrounding acute inflammation. Areas away from dysplasia did not show any positive staining for Glut-1. We conclude that two distinct patterns of Glut-1 expression may be found in colonic epithelial proliferation: membranous staining, associated with dysplasia, and, heretofore not described, supranuclear staining which may be related to Glut-1 expression secondary to expression of specific growth factors and not necessarily related to dysplasia.

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June 2001
Volume 7 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Fogt F, Wellmann A, Urbanski SJ, Noffsinger A, Poremba C, Zimmerman RL and Alsaigh N: Glut-1 expression in dysplastic and regenerative lesions of the colon. Int J Mol Med 7: 615-619, 2001.
APA
Fogt, F., Wellmann, A., Urbanski, S.J., Noffsinger, A., Poremba, C., Zimmerman, R.L., & Alsaigh, N. (2001). Glut-1 expression in dysplastic and regenerative lesions of the colon. International Journal of Molecular Medicine, 7, 615-619. https://doi.org/10.3892/ijmm.7.6.615
MLA
Fogt, F., Wellmann, A., Urbanski, S. J., Noffsinger, A., Poremba, C., Zimmerman, R. L., Alsaigh, N."Glut-1 expression in dysplastic and regenerative lesions of the colon". International Journal of Molecular Medicine 7.6 (2001): 615-619.
Chicago
Fogt, F., Wellmann, A., Urbanski, S. J., Noffsinger, A., Poremba, C., Zimmerman, R. L., Alsaigh, N."Glut-1 expression in dysplastic and regenerative lesions of the colon". International Journal of Molecular Medicine 7, no. 6 (2001): 615-619. https://doi.org/10.3892/ijmm.7.6.615