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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
June 2001 Volume 7 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2001 Volume 7 Issue 6

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Article

Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis

  • Authors:
    • David M. Smith
    • Q. Ping Dou

  • View Affiliations / Copyright

    Affiliations: Drug Discovery Program, H. Lee Moffitt Cancer Center and Research Institute, Interdisciplinary Oncology Program and Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA
  • Pages: 645-652
    |
    Published online on: June 1, 2001
       https://doi.org/10.3892/ijmm.7.6.645
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Abstract

Consistent with the putative role of green tea in cancer prevention, tea polyphenols have previously been shown to inhibit tumor cell proliferation by inducing G1 or G2/M cell cycle arrests, also documented is their ability to induce apoptosis (programmed cell death). However, it is unclear whether or not the cell cycle effects of polyphenols are related to their cell death-inducing ability. Here we report that the tea polyphenol (-)-epigallocatechin (EGC) inhibits DNA replication in three leukemia cancer cell lines, Jurkat T, HL-60 and K562. Among all the tested tea polyphenols, EGC was found to be the most potent in accumulation of S phase cells and inhibition of the S-G2 progression. In addition, EGC-mediated inhibition of S phase progression results in induction of apoptosis, as determined by sub-G1 cell population, breakage of endonuclear DNA, cleavage of poly(ADP-ribose) polymerase and loss of cell viability. When used in cells containing low S and high G1 and G2/M populations, EGC did not induce apoptosis. Furthermore, EGC did not inhibit M-G1 transition. Our finding that EGC inhibits S phase progression that results in leukemia cell death provides a novel and plausible molecular mechanism for how green tea may inhibit the growth of rapidly proliferating neoplastic cells.

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Copy and paste a formatted citation
Spandidos Publications style
Smith DM and Dou QP: Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis. Int J Mol Med 7: 645-652, 2001.
APA
Smith, D.M., & Dou, Q.P. (2001). Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis. International Journal of Molecular Medicine, 7, 645-652. https://doi.org/10.3892/ijmm.7.6.645
MLA
Smith, D. M., Dou, Q. P."Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis". International Journal of Molecular Medicine 7.6 (2001): 645-652.
Chicago
Smith, D. M., Dou, Q. P."Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis". International Journal of Molecular Medicine 7, no. 6 (2001): 645-652. https://doi.org/10.3892/ijmm.7.6.645
Copy and paste a formatted citation
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Spandidos Publications style
Smith DM and Dou QP: Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis. Int J Mol Med 7: 645-652, 2001.
APA
Smith, D.M., & Dou, Q.P. (2001). Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis. International Journal of Molecular Medicine, 7, 645-652. https://doi.org/10.3892/ijmm.7.6.645
MLA
Smith, D. M., Dou, Q. P."Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis". International Journal of Molecular Medicine 7.6 (2001): 645-652.
Chicago
Smith, D. M., Dou, Q. P."Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis". International Journal of Molecular Medicine 7, no. 6 (2001): 645-652. https://doi.org/10.3892/ijmm.7.6.645
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