Proliferating cell nuclear antigen labeling index and p53 expression predict outcome for breast cancer patients with four or more lymph node metastases

  • Authors:
    • Tsutomu Takashima
    • Naoyoshi Onoda
    • Tetsuro Ishikawa
    • Yoshinari Ogawa
    • Yasuyuki Kato
    • Yasuhisa Fujimoto
    • Michio Sowa
    • Kosei Hirakawa-Y.S. Chung
  • View Affiliations

  • Published online on: August 1, 2001     https://doi.org/10.3892/ijmm.8.2.159
  • Pages: 159-163
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Abstract

In general, extensive lymph node metastasis indicates poor prognosis in breast cancer. Nevertheless, some patients with this condition survive for a long time without recurrent disease. This study involved 112 breast cancer patients with four or more lymph node metastases and without distant metastasis who underwent surgery. p53 expression was associated with shorter overall and disease-free survival. High PCNA labeling index was associated with shorter overall disease-free survival. p53-negative and low-PCNA patients survived much longer than p53-positive and high-PCNA patients. This study showed that p53-negative or low-PCNA index patients have relatively good prognoses despite extensive lymph node metastasis.

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August 2001
Volume 8 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Takashima T, Onoda N, Ishikawa T, Ogawa Y, Kato Y, Fujimoto Y, Sowa M and Hirakawa-Y.S. Chung K: Proliferating cell nuclear antigen labeling index and p53 expression predict outcome for breast cancer patients with four or more lymph node metastases. Int J Mol Med 8: 159-163, 2001
APA
Takashima, T., Onoda, N., Ishikawa, T., Ogawa, Y., Kato, Y., Fujimoto, Y. ... Hirakawa-Y.S. Chung, K. (2001). Proliferating cell nuclear antigen labeling index and p53 expression predict outcome for breast cancer patients with four or more lymph node metastases. International Journal of Molecular Medicine, 8, 159-163. https://doi.org/10.3892/ijmm.8.2.159
MLA
Takashima, T., Onoda, N., Ishikawa, T., Ogawa, Y., Kato, Y., Fujimoto, Y., Sowa, M., Hirakawa-Y.S. Chung, K."Proliferating cell nuclear antigen labeling index and p53 expression predict outcome for breast cancer patients with four or more lymph node metastases". International Journal of Molecular Medicine 8.2 (2001): 159-163.
Chicago
Takashima, T., Onoda, N., Ishikawa, T., Ogawa, Y., Kato, Y., Fujimoto, Y., Sowa, M., Hirakawa-Y.S. Chung, K."Proliferating cell nuclear antigen labeling index and p53 expression predict outcome for breast cancer patients with four or more lymph node metastases". International Journal of Molecular Medicine 8, no. 2 (2001): 159-163. https://doi.org/10.3892/ijmm.8.2.159