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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September 2001 Volume 8 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2001 Volume 8 Issue 3

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Article

Angiogenic activity of leptin in the chick embryo chorioallantoic membrane is in part mediated by endogenous fibroblast growth factor-2

  • Authors:
    • D. Ribatti
    • B. Nico
    • A. S. Belloni
    • A. Vacca
    • L. Roncali
    • G. G. Nussdorfer

  • View Affiliations / Copyright

    Affiliations: Department of Human Anatomy and Histology, Policlinico, I-70124 Bari, Italy
  • Pages: 265-268
    |
    Published online on: September 1, 2001
       https://doi.org/10.3892/ijmm.8.3.265
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Abstract

Recently, it has been demonstrated that leptin, the product of the ob gene, playing a key role in the regulation of body weight, is angiogenic in vitro and in vivo. In this study we investigated the angiogenic potential of human leptin in vivo by using the chick embryo chorioallantoic membrane (CAM) assay, with the aim to establish whether this angiogenic activity is partly dependent on endogenous fibroblast growth factor-2 (FGF-2), which is normally expressed during CAM development. Results showed that leptin is able to stimulate angiogenesis and that the angiogenic response is similar to that obtained with FGF-2. The stimulating property of leptin is specific, as the application of anti-leptin antibodies onto the CAM significantly inhibits the angiogenic response. Moreover, this angiogenic activity is in part due to the activation of endogenous FGF-2. The application of anti-FGF-2 antibodies reduces the angiogenic response to leptin by 40%. Our study confirms that leptin is angiogenic in vivo and suggests that, at least in the chick CAM, its activity is in part mediated by the activation of endogenous FGF-2.

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Copy and paste a formatted citation
Spandidos Publications style
Ribatti D, Nico B, Belloni AS, Vacca A, Roncali L and Nussdorfer GG: Angiogenic activity of leptin in the chick embryo chorioallantoic membrane is in part mediated by endogenous fibroblast growth factor-2. Int J Mol Med 8: 265-268, 2001.
APA
Ribatti, D., Nico, B., Belloni, A.S., Vacca, A., Roncali, L., & Nussdorfer, G.G. (2001). Angiogenic activity of leptin in the chick embryo chorioallantoic membrane is in part mediated by endogenous fibroblast growth factor-2. International Journal of Molecular Medicine, 8, 265-268. https://doi.org/10.3892/ijmm.8.3.265
MLA
Ribatti, D., Nico, B., Belloni, A. S., Vacca, A., Roncali, L., Nussdorfer, G. G."Angiogenic activity of leptin in the chick embryo chorioallantoic membrane is in part mediated by endogenous fibroblast growth factor-2". International Journal of Molecular Medicine 8.3 (2001): 265-268.
Chicago
Ribatti, D., Nico, B., Belloni, A. S., Vacca, A., Roncali, L., Nussdorfer, G. G."Angiogenic activity of leptin in the chick embryo chorioallantoic membrane is in part mediated by endogenous fibroblast growth factor-2". International Journal of Molecular Medicine 8, no. 3 (2001): 265-268. https://doi.org/10.3892/ijmm.8.3.265
Copy and paste a formatted citation
x
Spandidos Publications style
Ribatti D, Nico B, Belloni AS, Vacca A, Roncali L and Nussdorfer GG: Angiogenic activity of leptin in the chick embryo chorioallantoic membrane is in part mediated by endogenous fibroblast growth factor-2. Int J Mol Med 8: 265-268, 2001.
APA
Ribatti, D., Nico, B., Belloni, A.S., Vacca, A., Roncali, L., & Nussdorfer, G.G. (2001). Angiogenic activity of leptin in the chick embryo chorioallantoic membrane is in part mediated by endogenous fibroblast growth factor-2. International Journal of Molecular Medicine, 8, 265-268. https://doi.org/10.3892/ijmm.8.3.265
MLA
Ribatti, D., Nico, B., Belloni, A. S., Vacca, A., Roncali, L., Nussdorfer, G. G."Angiogenic activity of leptin in the chick embryo chorioallantoic membrane is in part mediated by endogenous fibroblast growth factor-2". International Journal of Molecular Medicine 8.3 (2001): 265-268.
Chicago
Ribatti, D., Nico, B., Belloni, A. S., Vacca, A., Roncali, L., Nussdorfer, G. G."Angiogenic activity of leptin in the chick embryo chorioallantoic membrane is in part mediated by endogenous fibroblast growth factor-2". International Journal of Molecular Medicine 8, no. 3 (2001): 265-268. https://doi.org/10.3892/ijmm.8.3.265
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