Synergistic insulinotropic effects of succinic acid dimethyl ester and exendin-4 in anaesthetized rats

  • Authors:
    • J. Cancelas
    • M. L. Villanueva-Penacarrillo
    • I. Valverde
    • W. J. Malaisse
  • View Affiliations

  • Published online on: September 1, 2001     https://doi.org/10.3892/ijmm.8.3.269
  • Pages: 269-271
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

It was recently proposed that suitable succinic acid esters could be used to potentiate the insulinotropic action of glucagon-like peptide 1 (GLP-1) in the treatment of type-2 diabetes mellitus. In such a perspective, the present study aimed mainly at investigating whether exendin-4 (Ex-4), a peptide structurally related to GLP-1(7-36)amide, and succinic acid dimethyl ester (SAD) also act synergistically upon insulin secretion in anaesthetized rats. Despite a higher plasma insulin concentration in SAD-infused rats (5.5±1.1 ng/ml) than in saline-infused animals (1.9±0.7 ng/ml), the intravenous injection of Ex-4 augmented to a greater extent the plasma concentration of insulin in the former rats (+7.4±2.5 ng/ml) than in the latter animals (+2.8±0.6 ng/ml). These findings document that the insulinotropic actions of Ex-4 and GLP-1 display comparable nutrient dependency, being both potentiated by a non-glucidic nutrient secretagogue such as SAD.

Related Articles

Journal Cover

September 2001
Volume 8 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cancelas J, Villanueva-Penacarrillo ML, Valverde I and Malaisse WJ: Synergistic insulinotropic effects of succinic acid dimethyl ester and exendin-4 in anaesthetized rats. Int J Mol Med 8: 269-271, 2001
APA
Cancelas, J., Villanueva-Penacarrillo, M.L., Valverde, I., & Malaisse, W.J. (2001). Synergistic insulinotropic effects of succinic acid dimethyl ester and exendin-4 in anaesthetized rats. International Journal of Molecular Medicine, 8, 269-271. https://doi.org/10.3892/ijmm.8.3.269
MLA
Cancelas, J., Villanueva-Penacarrillo, M. L., Valverde, I., Malaisse, W. J."Synergistic insulinotropic effects of succinic acid dimethyl ester and exendin-4 in anaesthetized rats". International Journal of Molecular Medicine 8.3 (2001): 269-271.
Chicago
Cancelas, J., Villanueva-Penacarrillo, M. L., Valverde, I., Malaisse, W. J."Synergistic insulinotropic effects of succinic acid dimethyl ester and exendin-4 in anaesthetized rats". International Journal of Molecular Medicine 8, no. 3 (2001): 269-271. https://doi.org/10.3892/ijmm.8.3.269