Accumulation of p53 in esophageal squamous cell carcinoma

Chino,O.; Kijima,H.; Shimada,H.; Nishi,T.; Tanaka,H.; Kise,Y.; Kenmochi,T.; Himeno,S.; Machimura,T.; Tanaka,M.; Inokuchi,S.; Tajima,T.; Osamura,R. Y.; Makuuchi,H.

doi:10.3892/ijmm.8.4.359

October 2001 Volume 8 Issue 4

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October 2001 Volume 8 Issue 4

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Article

Accumulation of p53 in esophageal squamous cell carcinoma

Authors:
- O. Chino
- H. Kijima
- H. Shimada
- T. Nishi
- H. Tanaka
- Y. Kise
- T. Kenmochi
- S. Himeno
- T. Machimura
- M. Tanaka
- S. Inokuchi
- T. Tajima
- R. Y. Osamura
- H. Makuuchi
View Affiliations / Copyright

Affiliations: Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan
Pages: 359-363
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Published online on: October 1, 2001

https://doi.org/10.3892/ijmm.8.4.359
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Abstract

p53 is one of the most important tumor suppressor genes. Mutation of the p53 gene can be detected immunohistochemically as over-expression of its protein in the nucleus. The p53 gene product is known to regulate cell growth and proliferation. Genetic alterations related to the carcinogenesis or progression of esophageal cancer are poorly understood. We examined accumulation of p53 protein in esophageal squamous cell carcinomas including early-stage cancers, and its clinicopathological significance. p53 immunoreactivity in the cancer tissues was found in 61 (79.2%) of 77 esophageal squamous cell carcinomas. Over-expression of p53 protein (diffusely and focally positive staining) was seen in 70.1% (54/77). p53 over-expression was detected not only in the cases of in situ or intramucosal carcinomas, but also in invasive carcinomas. No significant correlations were found between p53 over-expression and clinicopathological features such as depth of tumor invasion, lymph node metastasis or venous/lymphatic invasion. These results suggested that p53 mutations may be closely associated with the early-stage of pre-invasive esophageal carcinoma, and p53 gene mutations may play an important role in the carcinogenesis of human esophageal cancer.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Accumulation of p53 in esophageal squamous cell carcinoma

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