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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2001 Volume 8 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2001 Volume 8 Issue 4

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Review

Clinical aspects of disrupted Hedgehog signaling (Review)

  • Authors:
    • Monika Oldakr
    • Tomasz Grzela
    • Maciej Lazarczyk
    • Jacek Malejczyk
    • Piotr Skopinski

  • View Affiliations / Copyright

    Affiliations: Laboratory for Molecular Cell Biology, Department of Histology and Embryology, Center of Biostructure Research, Medical University of Warsaw, PL-02004 Warsaw, Poland
  • Pages: 445-452
    |
    Published online on: October 1, 2001
       https://doi.org/10.3892/ijmm.8.4.445
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Abstract

The Hedgehog (HH) signaling pathway is involved in patterning and development of a variety of organ systems, including the nervous system, the skeletal system, the craniofacial structures, and the gastrointestinal tract. Recent evidence also implicates this signaling pathway in the postembryonic regulation of stem-cell number in epithelia and blood. The family of HH proteins consists of at least three different members, i.e., sonic HH (SHH), Indian HH (IHH), and desert HH (DHH). SHH is the most broadly expressed member of this family and is probably responsible for the major effects of this signaling pathway. The HH signal is received and transduced via a specific receptor complex composed of patched (PTCH) and smoothened (SMOH) transmembrane proteins. Abnormalities in this signaling cascade have been found in various developmental pathologies and neoplasms such as basal cell carcinoma. The abnormalities are associated with congenital or sporadic genetic alteration affecting function of different components of the HH signaling pathway, including SHH, PTCH, SMOH and GLI proteins.

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Copy and paste a formatted citation
Spandidos Publications style
Oldakr M, Grzela T, Lazarczyk M, Malejczyk J and Skopinski P: Clinical aspects of disrupted Hedgehog signaling (Review). Int J Mol Med 8: 445-452, 2001.
APA
Oldakr, M., Grzela, T., Lazarczyk, M., Malejczyk, J., & Skopinski, P. (2001). Clinical aspects of disrupted Hedgehog signaling (Review). International Journal of Molecular Medicine, 8, 445-452. https://doi.org/10.3892/ijmm.8.4.445
MLA
Oldakr, M., Grzela, T., Lazarczyk, M., Malejczyk, J., Skopinski, P."Clinical aspects of disrupted Hedgehog signaling (Review)". International Journal of Molecular Medicine 8.4 (2001): 445-452.
Chicago
Oldakr, M., Grzela, T., Lazarczyk, M., Malejczyk, J., Skopinski, P."Clinical aspects of disrupted Hedgehog signaling (Review)". International Journal of Molecular Medicine 8, no. 4 (2001): 445-452. https://doi.org/10.3892/ijmm.8.4.445
Copy and paste a formatted citation
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Spandidos Publications style
Oldakr M, Grzela T, Lazarczyk M, Malejczyk J and Skopinski P: Clinical aspects of disrupted Hedgehog signaling (Review). Int J Mol Med 8: 445-452, 2001.
APA
Oldakr, M., Grzela, T., Lazarczyk, M., Malejczyk, J., & Skopinski, P. (2001). Clinical aspects of disrupted Hedgehog signaling (Review). International Journal of Molecular Medicine, 8, 445-452. https://doi.org/10.3892/ijmm.8.4.445
MLA
Oldakr, M., Grzela, T., Lazarczyk, M., Malejczyk, J., Skopinski, P."Clinical aspects of disrupted Hedgehog signaling (Review)". International Journal of Molecular Medicine 8.4 (2001): 445-452.
Chicago
Oldakr, M., Grzela, T., Lazarczyk, M., Malejczyk, J., Skopinski, P."Clinical aspects of disrupted Hedgehog signaling (Review)". International Journal of Molecular Medicine 8, no. 4 (2001): 445-452. https://doi.org/10.3892/ijmm.8.4.445
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