Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats

  • Authors:
    • J. Cancelas
    • M. L. Villanueva-Penacarrillo
    • I. Valverde
    • W. J. Malaisse
  • View Affiliations

  • Published online on: November 1, 2001     https://doi.org/10.3892/ijmm.8.5.531
  • Pages: 531-532
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Abstract

The dimethyl ester of L-glutamic acid (DMG) stimulates insulin release and was proposed as a possible insulinotropic tool in the treatment of non-insulin-dependent diabetes. In such a perspective, it was investigated whether DMG enhances the B-cell secretory response to GLP-1 in fed anaesthetized rats. The primed constant infusion of DMG (1.0 μmol and then 0.5 μmol/min, both per g body wt.) provoked a rapid and sustained increase in plasma insulin concentration and augmented the release of insulin caused by GLP-1. Thus, DMG indeed appears as a suitable tool to potentiate the insulinotropic action of GLP-1.

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November 2001
Volume 8 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Cancelas J, Villanueva-Penacarrillo ML, Valverde I and Malaisse WJ: Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats. Int J Mol Med 8: 531-532, 2001.
APA
Cancelas, J., Villanueva-Penacarrillo, M.L., Valverde, I., & Malaisse, W.J. (2001). Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats. International Journal of Molecular Medicine, 8, 531-532. https://doi.org/10.3892/ijmm.8.5.531
MLA
Cancelas, J., Villanueva-Penacarrillo, M. L., Valverde, I., Malaisse, W. J."Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats". International Journal of Molecular Medicine 8.5 (2001): 531-532.
Chicago
Cancelas, J., Villanueva-Penacarrillo, M. L., Valverde, I., Malaisse, W. J."Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats". International Journal of Molecular Medicine 8, no. 5 (2001): 531-532. https://doi.org/10.3892/ijmm.8.5.531