An antibody against anemia-inducing substance inhibits cation influx in red blood cells from cancer patients

  • Authors:
    • K.-I. Honda
    • O. Ishiko
    • S. Ogita
  • View Affiliations

  • Published online on: December 1, 2001     https://doi.org/10.3892/ijmm.8.6.629
  • Pages: 629-631
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Abstract

Resealed ghost of red blood cells (RBCs) from advanced cancer patients includes proteins with antigenicities common to an anemia-inducing substance that we separated from plasma of patients with advanced malignant neoplasms. Although cation influx in vitro in RBCs from a cancer patient is larger than that from a normal healthy volunteer, an antibody against anemia-inducing substance inhibited the in vitro cation influx in RBCs from the cancer patient. Activation of the cation influx with N-ethylmaleimide after reaction with the antibody reversed the effect to create a greater cation influx in RBCs from the patient, as compared with that from the healthy volunteer.

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December 2001
Volume 8 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Honda, K., Ishiko, O., & Ogita, S. (2001). An antibody against anemia-inducing substance inhibits cation influx in red blood cells from cancer patients. International Journal of Molecular Medicine, 8, 629-631. https://doi.org/10.3892/ijmm.8.6.629
MLA
Honda, K., Ishiko, O., Ogita, S."An antibody against anemia-inducing substance inhibits cation influx in red blood cells from cancer patients". International Journal of Molecular Medicine 8.6 (2001): 629-631.
Chicago
Honda, K., Ishiko, O., Ogita, S."An antibody against anemia-inducing substance inhibits cation influx in red blood cells from cancer patients". International Journal of Molecular Medicine 8, no. 6 (2001): 629-631. https://doi.org/10.3892/ijmm.8.6.629