Genetic alterations of Carney complex are not present in sporadic cardiac myxomas

  • Authors:
    • Franz Fogt
    • Robert L. Zimmerman
    • Christopher J. Hartmann
    • Charlotte A. Brown
    • Navneet Narula
  • View Affiliations

  • Published online on: January 1, 2002     https://doi.org/10.3892/ijmm.9.1.59
  • Pages: 59-60
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Abstract

Cardiac myxomas are the most frequent cardiac tumors and cause for significant morbidity and mortality. Recent evidence indicates that cardiac myxomas are, in fact, neoplasms rather than organized thrombi. Cardiac myxomas may present as solitary lesions or in association with the Carney complex. Carney complex has been linked to chromosome 2p16 and the PRKAR1A gene at 17q22-24. In this study, we analyzed sporadic cardiac myxomas to evaluate whether the genetic alterations seen in Carney complex are present in non Carney complex associated cardiac myxomas as well. We analyzed microdissected material from 13 patients with cardiac myxomas for the markers PRKAR1 9CA, D2S2153, D2S2251 and D2S123. None of the cases demonstrated loss of heterozygosity or definite band changes suggestive of microsatellite instability for any of the markers used. We conclude that sporadic cardiac myxomas are genetically not related to Carney complex and most likely do not represent an incomplete form of Carney complex.

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January 2002
Volume 9 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Fogt F, Zimmerman RL, Hartmann CJ, Brown CA and Narula N: Genetic alterations of Carney complex are not present in sporadic cardiac myxomas. Int J Mol Med 9: 59-60, 2002
APA
Fogt, F., Zimmerman, R.L., Hartmann, C.J., Brown, C.A., & Narula, N. (2002). Genetic alterations of Carney complex are not present in sporadic cardiac myxomas. International Journal of Molecular Medicine, 9, 59-60. https://doi.org/10.3892/ijmm.9.1.59
MLA
Fogt, F., Zimmerman, R. L., Hartmann, C. J., Brown, C. A., Narula, N."Genetic alterations of Carney complex are not present in sporadic cardiac myxomas". International Journal of Molecular Medicine 9.1 (2002): 59-60.
Chicago
Fogt, F., Zimmerman, R. L., Hartmann, C. J., Brown, C. A., Narula, N."Genetic alterations of Carney complex are not present in sporadic cardiac myxomas". International Journal of Molecular Medicine 9, no. 1 (2002): 59-60. https://doi.org/10.3892/ijmm.9.1.59