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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January 2002 Volume 9 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2002 Volume 9 Issue 1

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Article

Genetic alterations of Carney complex are not present in sporadic cardiac myxomas

  • Authors:
    • Franz Fogt
    • Robert L. Zimmerman
    • Christopher J. Hartmann
    • Charlotte A. Brown
    • Navneet Narula

  • View Affiliations / Copyright

    Affiliations: Presbyterian Medical Center, University of Pennsylvania, Philadelphia, PA 19104, USA
  • Pages: 59-60
    |
    Published online on: January 1, 2002
       https://doi.org/10.3892/ijmm.9.1.59
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Abstract

Cardiac myxomas are the most frequent cardiac tumors and cause for significant morbidity and mortality. Recent evidence indicates that cardiac myxomas are, in fact, neoplasms rather than organized thrombi. Cardiac myxomas may present as solitary lesions or in association with the Carney complex. Carney complex has been linked to chromosome 2p16 and the PRKAR1A gene at 17q22-24. In this study, we analyzed sporadic cardiac myxomas to evaluate whether the genetic alterations seen in Carney complex are present in non Carney complex associated cardiac myxomas as well. We analyzed microdissected material from 13 patients with cardiac myxomas for the markers PRKAR1 9CA, D2S2153, D2S2251 and D2S123. None of the cases demonstrated loss of heterozygosity or definite band changes suggestive of microsatellite instability for any of the markers used. We conclude that sporadic cardiac myxomas are genetically not related to Carney complex and most likely do not represent an incomplete form of Carney complex.

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Copy and paste a formatted citation
Spandidos Publications style
Fogt F, Zimmerman RL, Hartmann CJ, Brown CA and Narula N: Genetic alterations of Carney complex are not present in sporadic cardiac myxomas. Int J Mol Med 9: 59-60, 2002.
APA
Fogt, F., Zimmerman, R.L., Hartmann, C.J., Brown, C.A., & Narula, N. (2002). Genetic alterations of Carney complex are not present in sporadic cardiac myxomas. International Journal of Molecular Medicine, 9, 59-60. https://doi.org/10.3892/ijmm.9.1.59
MLA
Fogt, F., Zimmerman, R. L., Hartmann, C. J., Brown, C. A., Narula, N."Genetic alterations of Carney complex are not present in sporadic cardiac myxomas". International Journal of Molecular Medicine 9.1 (2002): 59-60.
Chicago
Fogt, F., Zimmerman, R. L., Hartmann, C. J., Brown, C. A., Narula, N."Genetic alterations of Carney complex are not present in sporadic cardiac myxomas". International Journal of Molecular Medicine 9, no. 1 (2002): 59-60. https://doi.org/10.3892/ijmm.9.1.59
Copy and paste a formatted citation
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Spandidos Publications style
Fogt F, Zimmerman RL, Hartmann CJ, Brown CA and Narula N: Genetic alterations of Carney complex are not present in sporadic cardiac myxomas. Int J Mol Med 9: 59-60, 2002.
APA
Fogt, F., Zimmerman, R.L., Hartmann, C.J., Brown, C.A., & Narula, N. (2002). Genetic alterations of Carney complex are not present in sporadic cardiac myxomas. International Journal of Molecular Medicine, 9, 59-60. https://doi.org/10.3892/ijmm.9.1.59
MLA
Fogt, F., Zimmerman, R. L., Hartmann, C. J., Brown, C. A., Narula, N."Genetic alterations of Carney complex are not present in sporadic cardiac myxomas". International Journal of Molecular Medicine 9.1 (2002): 59-60.
Chicago
Fogt, F., Zimmerman, R. L., Hartmann, C. J., Brown, C. A., Narula, N."Genetic alterations of Carney complex are not present in sporadic cardiac myxomas". International Journal of Molecular Medicine 9, no. 1 (2002): 59-60. https://doi.org/10.3892/ijmm.9.1.59
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