Identification of genes coding enzymes for ascomycin tetra-hydropyranose ring formation

  • Authors:
    • Takafumi Uchida
    • Fumihiro Fujimori
    • Naoki Nagata
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  • Published online on: February 1, 2002     https://doi.org/10.3892/ijmm.9.2.141
  • Pages: 141-145
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Abstract

Macrocyclic polyketides have generated great interest in biosynthetic chemistry because of the structural complexity and medicinal activities. The synthetic genes consist of the number and type of active sites of modular polyketide synthases. The cosmid library - prepared with the ascomycin (an antibiotics with immunosuppressive activity) - producer, Streptomyces sp. AA6554 genome was screened with an ascomycin ketosynthase gene probe, and one and a half modules were isolated. Database analysis shows that one of the modules consists of the genes coding a series of enzymes for the tetra-hydropyranose ring synthesis.

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February 2002
Volume 9 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Uchida T, Fujimori F and Nagata N: Identification of genes coding enzymes for ascomycin tetra-hydropyranose ring formation. Int J Mol Med 9: 141-145, 2002
APA
Uchida, T., Fujimori, F., & Nagata, N. (2002). Identification of genes coding enzymes for ascomycin tetra-hydropyranose ring formation. International Journal of Molecular Medicine, 9, 141-145. https://doi.org/10.3892/ijmm.9.2.141
MLA
Uchida, T., Fujimori, F., Nagata, N."Identification of genes coding enzymes for ascomycin tetra-hydropyranose ring formation". International Journal of Molecular Medicine 9.2 (2002): 141-145.
Chicago
Uchida, T., Fujimori, F., Nagata, N."Identification of genes coding enzymes for ascomycin tetra-hydropyranose ring formation". International Journal of Molecular Medicine 9, no. 2 (2002): 141-145. https://doi.org/10.3892/ijmm.9.2.141