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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
March 2002 Volume 9 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2002 Volume 9 Issue 3

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Article

RFX-B, a MHC class II transcription factor, suppressed in human colorectal adenocarcinomas

  • Authors:
    • Jan Dimberg
    • Anders Hugander
    • Britt-Marie Hall-Karlsson
    • Allan Sirsjo

  • View Affiliations / Copyright

    Affiliations: Department of Natural Science and Biomedicine, University College of Health Sciences, S-551 11 Jonkoping, Sweden. jan.dimberg@hhj.hj.se
  • Pages: 213-216
    |
    Published online on: March 1, 2002
       https://doi.org/10.3892/ijmm.9.3.213
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Abstract

Regulatory factor X (RFX) is an essential MHC class II transcription factor and contains three distinct subunits of which RFX-B is one. Aberrant expression of MHC class II genes is associated with autoimmunity, tumour growth and failure to mount an immune response. RFX-B protein expression in human colorectal adenocarcinomas and in normal adjacent tissue was analysed in this study. Western blot analysis showed a suppression of nuclear RFX-B protein in the tumour tissue. Immunohistochemistry revealed that the RFX-B protein levels in macrophages were generally lower in colorectal cancerous tissue compared to adjacent non-cancerous tissue and that focally and not frequently tumour and normal epithelial cells were stained weakly for RFX-B. As the expression of MHC class II correlates with the intensity of the immune response system these results may support the idea that cancer is associated with immunodeficiency and that low levels of RFX-B in interstitial macrophages could partly explain this thesis.

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Copy and paste a formatted citation
Spandidos Publications style
Dimberg J, Hugander A, Hall-Karlsson B and Sirsjo A: RFX-B, a MHC class II transcription factor, suppressed in human colorectal adenocarcinomas. Int J Mol Med 9: 213-216, 2002.
APA
Dimberg, J., Hugander, A., Hall-Karlsson, B., & Sirsjo, A. (2002). RFX-B, a MHC class II transcription factor, suppressed in human colorectal adenocarcinomas. International Journal of Molecular Medicine, 9, 213-216. https://doi.org/10.3892/ijmm.9.3.213
MLA
Dimberg, J., Hugander, A., Hall-Karlsson, B., Sirsjo, A."RFX-B, a MHC class II transcription factor, suppressed in human colorectal adenocarcinomas". International Journal of Molecular Medicine 9.3 (2002): 213-216.
Chicago
Dimberg, J., Hugander, A., Hall-Karlsson, B., Sirsjo, A."RFX-B, a MHC class II transcription factor, suppressed in human colorectal adenocarcinomas". International Journal of Molecular Medicine 9, no. 3 (2002): 213-216. https://doi.org/10.3892/ijmm.9.3.213
Copy and paste a formatted citation
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Spandidos Publications style
Dimberg J, Hugander A, Hall-Karlsson B and Sirsjo A: RFX-B, a MHC class II transcription factor, suppressed in human colorectal adenocarcinomas. Int J Mol Med 9: 213-216, 2002.
APA
Dimberg, J., Hugander, A., Hall-Karlsson, B., & Sirsjo, A. (2002). RFX-B, a MHC class II transcription factor, suppressed in human colorectal adenocarcinomas. International Journal of Molecular Medicine, 9, 213-216. https://doi.org/10.3892/ijmm.9.3.213
MLA
Dimberg, J., Hugander, A., Hall-Karlsson, B., Sirsjo, A."RFX-B, a MHC class II transcription factor, suppressed in human colorectal adenocarcinomas". International Journal of Molecular Medicine 9.3 (2002): 213-216.
Chicago
Dimberg, J., Hugander, A., Hall-Karlsson, B., Sirsjo, A."RFX-B, a MHC class II transcription factor, suppressed in human colorectal adenocarcinomas". International Journal of Molecular Medicine 9, no. 3 (2002): 213-216. https://doi.org/10.3892/ijmm.9.3.213
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