Lack of Bcl10 mutations in malignant cartilaginous tumors

  • Authors:
    • Yong-Koo Park
    • Hye-Rim Park
    • Youn-Wha Kim
    • Sung-Gil Chi
    • K. Krishnan Unni
  • View Affiliations

  • Published online on: March 1, 2002     https://doi.org/10.3892/ijmm.9.3.217
  • Pages: 217-219
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Abstract

The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas. Somatic mutations of Bcl10 were found in not only t(1;14)-bearing MALT lymphomas, but also a wide range of other tumors. To clarify the actual frequency and spectrum of Bcl10 mutations in primary malignant chondrogenic tumors, we examined 89 cases of malignant chondrogenic tumors comprising 17 conventional chondrosarcomas, 33 mesenchymal chondrosarcomas, and 39 clear cell chondrosarcomas. Polymerase chain reaction single-stranded conformation polymorphism and sequencing analyses were done. No Bcl10 mutations were found in our series of malignant chondrogenic tumors. While screening for mutations, we also found three polymorphisms at codons 8 exon 1 of the Bcl10 gene. Our results strongly suggest that somatic mutations of Bcl10 are extremly rare in malignant cartilaginous tumors and do not commonly contribute to their molecular pathogenesis.

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March 2002
Volume 9 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Park Y, Park H, Kim Y, Chi S and Unni KK: Lack of Bcl10 mutations in malignant cartilaginous tumors. Int J Mol Med 9: 217-219, 2002
APA
Park, Y., Park, H., Kim, Y., Chi, S., & Unni, K.K. (2002). Lack of Bcl10 mutations in malignant cartilaginous tumors. International Journal of Molecular Medicine, 9, 217-219. https://doi.org/10.3892/ijmm.9.3.217
MLA
Park, Y., Park, H., Kim, Y., Chi, S., Unni, K. K."Lack of Bcl10 mutations in malignant cartilaginous tumors". International Journal of Molecular Medicine 9.3 (2002): 217-219.
Chicago
Park, Y., Park, H., Kim, Y., Chi, S., Unni, K. K."Lack of Bcl10 mutations in malignant cartilaginous tumors". International Journal of Molecular Medicine 9, no. 3 (2002): 217-219. https://doi.org/10.3892/ijmm.9.3.217