Abnormal accumulation in lipopolysaccharide in biliary epithelial cells of rats with self-filling blind loop

Koga,Hironori; Sakisaka,Shotaro; Yoshitake,Masao; Harada,Masaru; Kumemura,Hiroto; Hanada,Shinichiro; Taniguchi,Eitaro; Kawaguchi,Takumi; Kumashiro,Ryukichi; Sata,Michio

doi:10.3892/ijmm.9.6.621

June 2002 Volume 9 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

June 2002 Volume 9 Issue 6

Full Size Image

Article

Abnormal accumulation in lipopolysaccharide in biliary epithelial cells of rats with self-filling blind loop

Authors:
- Hironori Koga
- Shotaro Sakisaka
- Masao Yoshitake
- Masaru Harada
- Hiroto Kumemura
- Shinichiro Hanada
- Eitaro Taniguchi
- Takumi Kawaguchi
- Ryukichi Kumashiro
- Michio Sata
View Affiliations / Copyright

Affiliations: Second Department of Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan. hirokoga@med.kurume-u.ac.jp
Pages: 621-626
|
Published online on: June 1, 2002

https://doi.org/10.3892/ijmm.9.6.621
Expand metrics +

Abstract

Primary sclerosing cholangitis (PSC) is known to be frequently associated with inflammatory bowel diseases. In a rat with self-filling blind loop (SFBL), a proposed animal model for PSC, hepatobiliary inflammation has previously been demonstrated. In this study, we assessed the involvement of lipopolysaccharide (LPS), a bacterial endotoxin, in the pathogenesis of hepatobiliary inflammation of the SFBL model. The hepatic localization of LPS was examined by immunohistochemistry using an anti-lipid A antibody. The portal blood concentration of LPS was measured by an endotoxin-specific chromogenic Limulus test (Endospecy test). LPS was localized in the biliary epithelial cells (BECs) of rats with SFBL, and the portal blood concentration of LPS was significantly higher than that of sham-operated rats. Development of hepatobiliary inflammation, peribiliary fibrosis, and injury to the intestinal mucosa were histologically confirmed. Constriction in the biliary trees was radiologically demonstrated. These findings suggested that abnormal accumulation of LPS, which may be derived from portal blood, in BECs was involved in the pathogenesis of hepatobiliary inflammation with intestinal injury.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Abnormal accumulation in lipopolysaccharide in biliary epithelial cells of rats with self-filling blind loop

This article is mentioned in:

Abstract

Related Articles