In silico study of a novel gene evolved from an ancestral SVIP gene and highly expressed in the adult mouse testes

  • Authors:
    • Momoko Yoshida
    • Akifumi Yamashita
    • Yoshiko Idoji
    • Seiji Nishiguchi
    • Kazunori Shimada
    • Teruo Yasunaga
    • Hiromichi Yamanishi
  • View Affiliations

  • Published online on: August 1, 2008     https://doi.org/10.3892/ijmm_00000001
  • Pages: 143-148
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Abstract

We found that a cDNA clone isolated from a mouse testis cDNA library, 1700015G11 (Mmu_15G11), corresponded to the most highly expressed testis-specific mRNA in the adult mouse. Although the Mmu_15G11 cDNA is predicted to encode a small protein consisting of 67 amino acid residues, it has not yet been functionally annotated and has been designated as an unclassifiable clone. Since the Mmu_15G11 protein possibly has a pivotal role in spermatogenesis, we initiated an in silico study of this clone, and revealed that an ancestral gene of 15G11 genes evolved from an ancestral gene for mammalian small valosin-containing protein-interacting protein (SVIP) genes by gene duplication. Although SVIP protein reportedly participates in endoplasmic reticulum-related protein degradation, 15G11 protein is predicted to be a nuclear protein and possibly participates in the interaction between proteins and nuclear DNA.

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August 2008
Volume 22 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yoshida M, Yamashita A, Idoji Y, Nishiguchi S, Shimada K, Yasunaga T and Yamanishi H: In silico study of a novel gene evolved from an ancestral SVIP gene and highly expressed in the adult mouse testes. Int J Mol Med 22: 143-148, 2008.
APA
Yoshida, M., Yamashita, A., Idoji, Y., Nishiguchi, S., Shimada, K., Yasunaga, T., & Yamanishi, H. (2008). In silico study of a novel gene evolved from an ancestral SVIP gene and highly expressed in the adult mouse testes. International Journal of Molecular Medicine, 22, 143-148. https://doi.org/10.3892/ijmm_00000001
MLA
Yoshida, M., Yamashita, A., Idoji, Y., Nishiguchi, S., Shimada, K., Yasunaga, T., Yamanishi, H."In silico study of a novel gene evolved from an ancestral SVIP gene and highly expressed in the adult mouse testes". International Journal of Molecular Medicine 22.2 (2008): 143-148.
Chicago
Yoshida, M., Yamashita, A., Idoji, Y., Nishiguchi, S., Shimada, K., Yasunaga, T., Yamanishi, H."In silico study of a novel gene evolved from an ancestral SVIP gene and highly expressed in the adult mouse testes". International Journal of Molecular Medicine 22, no. 2 (2008): 143-148. https://doi.org/10.3892/ijmm_00000001