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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2008 Volume 22 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2008 Volume 22 Issue 2

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Article

M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion

  • Authors:
    • Ryoko Ono
    • Junji Matsuoka
    • Tomoki Yamatsuji
    • Yoshio Naomoto
    • Noriaki Tanaka
    • Hideki Matsui
    • Masayuki Matsushita

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Graduate School of Medicine and Dentistry, Okayama University, Okayama 700-8558, Japan
  • Pages: 199-203
    |
    Published online on: August 1, 2008
       https://doi.org/10.3892/ijmm_00000009
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Abstract

Cell motility is involved in physiological and pathological processes such as the invasion and migration of cells. c-Jun N-terminal kinase (JNK) cascades are involved in the invasion and metastasis of cancer cells. However, little is known about the downstream signaling of JNK. In the present study, we used small interfering RNA (siRNA) directed against JNK1 to reduce its expression. We used microarray techniques to compare the gene expression profiles of epidermal growth factor (EGF)-stimulated HeLa cells with and without JNK1 siRNA treatment. We identified a JNK1 target gene, myosin phosphatase-Rho interacting protein (M-RIP). RNA interference-mediated inhibition of JNK1 strongly inhibited M-RIP mRNA expression induced by EGF, as well as the invasion of HeLa cells. In addition, M-RIP siRNA-treated cells showed significantly reduced invasive activity. Thus, a functional analysis of JNK1 and M-RIP with RNA interference reveals a critical role for this cascade in the invasive behavior of cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Ono R, Matsuoka J, Yamatsuji T, Naomoto Y, Tanaka N, Matsui H and Matsushita M: M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion. Int J Mol Med 22: 199-203, 2008.
APA
Ono, R., Matsuoka, J., Yamatsuji, T., Naomoto, Y., Tanaka, N., Matsui, H., & Matsushita, M. (2008). M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion. International Journal of Molecular Medicine, 22, 199-203. https://doi.org/10.3892/ijmm_00000009
MLA
Ono, R., Matsuoka, J., Yamatsuji, T., Naomoto, Y., Tanaka, N., Matsui, H., Matsushita, M."M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion". International Journal of Molecular Medicine 22.2 (2008): 199-203.
Chicago
Ono, R., Matsuoka, J., Yamatsuji, T., Naomoto, Y., Tanaka, N., Matsui, H., Matsushita, M."M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion". International Journal of Molecular Medicine 22, no. 2 (2008): 199-203. https://doi.org/10.3892/ijmm_00000009
Copy and paste a formatted citation
x
Spandidos Publications style
Ono R, Matsuoka J, Yamatsuji T, Naomoto Y, Tanaka N, Matsui H and Matsushita M: M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion. Int J Mol Med 22: 199-203, 2008.
APA
Ono, R., Matsuoka, J., Yamatsuji, T., Naomoto, Y., Tanaka, N., Matsui, H., & Matsushita, M. (2008). M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion. International Journal of Molecular Medicine, 22, 199-203. https://doi.org/10.3892/ijmm_00000009
MLA
Ono, R., Matsuoka, J., Yamatsuji, T., Naomoto, Y., Tanaka, N., Matsui, H., Matsushita, M."M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion". International Journal of Molecular Medicine 22.2 (2008): 199-203.
Chicago
Ono, R., Matsuoka, J., Yamatsuji, T., Naomoto, Y., Tanaka, N., Matsui, H., Matsushita, M."M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion". International Journal of Molecular Medicine 22, no. 2 (2008): 199-203. https://doi.org/10.3892/ijmm_00000009
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