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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2008 Volume 22 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2008 Volume 22 Issue 4

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Article

Derivation of hepato-pancreatic intermediate progenitor cells from a clonal mesenchymal stem cell line of rat bone marrow origin

  • Authors:
    • Takuro Masaka
    • Masahiro Miyazaki
    • Gang Du
    • Marhaen Hardjo
    • Masakiyo Sakaguchi
    • Mikiro Takaishi
    • Ken Kataoka
    • Kazuhide Yamamoto
    • Nam-Ho Huh

  • View Affiliations / Copyright

    Affiliations: Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata-Chou, Okayama, Japan
  • Pages: 447-452
    |
    Published online on: October 1, 2008
       https://doi.org/10.3892/ijmm_00000041
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Abstract

We have recently established a clonal mesenchymal stem cell line (rBM25/S3) from adult rat bone marrow. The cells have practically unlimited proliferation capacity (over 300 PDL), maintaining multipotency for differentiation. In the present study, we examined the potential for rBM25/S3 cells to differentiate into insulin-secreting cells. When cultured in the presence of HGF and FGF-4 on Matrigel, rBM25/S3 cells expressed genes specific to pancreatic β-cells as well as those specific to hepatocytes. They still maintained proliferation capacity with a doubling time of ≈30 h. These hepato-pancreatic intermediate progenitor cells, but not the original undifferentiated rBM25/S3 cells, were induced by the overexpression of PDX-1 to produce significant amounts of insulin in a manner responding to glucose concentration in medium. The present culture system indicates a direction for further studies aimed at the realization of cell transplantation therapy for type I diabetes mellitus.

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Copy and paste a formatted citation
Spandidos Publications style
Masaka T, Miyazaki M, Du G, Hardjo M, Sakaguchi M, Takaishi M, Kataoka K, Yamamoto K and Huh N: Derivation of hepato-pancreatic intermediate progenitor cells from a clonal mesenchymal stem cell line of rat bone marrow origin. Int J Mol Med 22: 447-452, 2008.
APA
Masaka, T., Miyazaki, M., Du, G., Hardjo, M., Sakaguchi, M., Takaishi, M. ... Huh, N. (2008). Derivation of hepato-pancreatic intermediate progenitor cells from a clonal mesenchymal stem cell line of rat bone marrow origin. International Journal of Molecular Medicine, 22, 447-452. https://doi.org/10.3892/ijmm_00000041
MLA
Masaka, T., Miyazaki, M., Du, G., Hardjo, M., Sakaguchi, M., Takaishi, M., Kataoka, K., Yamamoto, K., Huh, N."Derivation of hepato-pancreatic intermediate progenitor cells from a clonal mesenchymal stem cell line of rat bone marrow origin". International Journal of Molecular Medicine 22.4 (2008): 447-452.
Chicago
Masaka, T., Miyazaki, M., Du, G., Hardjo, M., Sakaguchi, M., Takaishi, M., Kataoka, K., Yamamoto, K., Huh, N."Derivation of hepato-pancreatic intermediate progenitor cells from a clonal mesenchymal stem cell line of rat bone marrow origin". International Journal of Molecular Medicine 22, no. 4 (2008): 447-452. https://doi.org/10.3892/ijmm_00000041
Copy and paste a formatted citation
x
Spandidos Publications style
Masaka T, Miyazaki M, Du G, Hardjo M, Sakaguchi M, Takaishi M, Kataoka K, Yamamoto K and Huh N: Derivation of hepato-pancreatic intermediate progenitor cells from a clonal mesenchymal stem cell line of rat bone marrow origin. Int J Mol Med 22: 447-452, 2008.
APA
Masaka, T., Miyazaki, M., Du, G., Hardjo, M., Sakaguchi, M., Takaishi, M. ... Huh, N. (2008). Derivation of hepato-pancreatic intermediate progenitor cells from a clonal mesenchymal stem cell line of rat bone marrow origin. International Journal of Molecular Medicine, 22, 447-452. https://doi.org/10.3892/ijmm_00000041
MLA
Masaka, T., Miyazaki, M., Du, G., Hardjo, M., Sakaguchi, M., Takaishi, M., Kataoka, K., Yamamoto, K., Huh, N."Derivation of hepato-pancreatic intermediate progenitor cells from a clonal mesenchymal stem cell line of rat bone marrow origin". International Journal of Molecular Medicine 22.4 (2008): 447-452.
Chicago
Masaka, T., Miyazaki, M., Du, G., Hardjo, M., Sakaguchi, M., Takaishi, M., Kataoka, K., Yamamoto, K., Huh, N."Derivation of hepato-pancreatic intermediate progenitor cells from a clonal mesenchymal stem cell line of rat bone marrow origin". International Journal of Molecular Medicine 22, no. 4 (2008): 447-452. https://doi.org/10.3892/ijmm_00000041
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