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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2008 Volume 22 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2008 Volume 22 Issue 4

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Article

Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1

  • Authors:
    • Sun-Ju Yi
    • Hyung-Taek Lee
    • John Groffen
    • Nora Heisterkamp

  • View Affiliations / Copyright

    Affiliations: Section of Molecular Carcinogenesis, Division of Hematology/Oncology, Ms#54, The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
  • Pages: 453-458
    |
    Published online on: October 1, 2008
       https://doi.org/10.3892/ijmm_00000042
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Abstract

The Bcr/Abl oncogene is responsible for the development of Ph-chromosome positive acute lymphoblastic leukemia and chronic myelogenous leukemia in humans. Previous studies demonstrated that Bcr/Abl expression is associated with elevated levels of activated Rap1, a small GTPase. Levels of activated Rap1 are determined by a balance between GTPase activating and G-nucleotide exchange factor activity. We show that Bcr/Abl forms a protein-protein complex with Spa-1, a GTPase activating protein for Rap1, both in COS-1 cells as well as in primary lymphoblastic leukemia cells from a transgenic P190 BCR/ABL mouse model. The interaction between Spa-1 and P190 did not affect the tyrosine kinase activity of P190, nor did Spa-1 become phosphorylated on tyrosine as a result of the interaction. P190 and Spa-1 co-localized to peripheral actin structures in primary lymphoblasts and expression of Spa-1 in the leukemic lymphoblasts decreased the migration of these cells. The binding of Bcr/Abl to Spa-1 may cause aberrant subcellular location of Spa-1 and affect migration of these cells.

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Copy and paste a formatted citation
Spandidos Publications style
Yi S, Lee H, Groffen J and Heisterkamp N: Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1. Int J Mol Med 22: 453-458, 2008.
APA
Yi, S., Lee, H., Groffen, J., & Heisterkamp, N. (2008). Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1. International Journal of Molecular Medicine, 22, 453-458. https://doi.org/10.3892/ijmm_00000042
MLA
Yi, S., Lee, H., Groffen, J., Heisterkamp, N."Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1". International Journal of Molecular Medicine 22.4 (2008): 453-458.
Chicago
Yi, S., Lee, H., Groffen, J., Heisterkamp, N."Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1". International Journal of Molecular Medicine 22, no. 4 (2008): 453-458. https://doi.org/10.3892/ijmm_00000042
Copy and paste a formatted citation
x
Spandidos Publications style
Yi S, Lee H, Groffen J and Heisterkamp N: Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1. Int J Mol Med 22: 453-458, 2008.
APA
Yi, S., Lee, H., Groffen, J., & Heisterkamp, N. (2008). Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1. International Journal of Molecular Medicine, 22, 453-458. https://doi.org/10.3892/ijmm_00000042
MLA
Yi, S., Lee, H., Groffen, J., Heisterkamp, N."Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1". International Journal of Molecular Medicine 22.4 (2008): 453-458.
Chicago
Yi, S., Lee, H., Groffen, J., Heisterkamp, N."Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1". International Journal of Molecular Medicine 22, no. 4 (2008): 453-458. https://doi.org/10.3892/ijmm_00000042
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