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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2008 Volume 22 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2008 Volume 22 Issue 4

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Article

Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-κB pathways in human multiple myeloma cells

  • Authors:
    • Min Yang
    • Jian Huang
    • Han-zhang Pan
    • Jie Jin

  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Institute of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou 310003, P.R. China
  • Pages: 489-496
    |
    Published online on: October 1, 2008
       https://doi.org/10.3892/ijmm_00000047
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Abstract

Human multiple myeloma is a presently incurable hematological malignancy and novel biologically based therapies are urgently needed. Triptolide (TPL) is a purified diterpenod isolated from the Chinese herb, Tripterygium wilfordii Hook. F that has shown antitumor activities in various cancer cell types. But its activity in Dex-resistant multiple myeloma cell lines and the main upstream signaling pathway has not been reported. Here we show that TPL induces apoptosis in dexamethasone-sensitive (MM.1S) and dexamethasone-resistant (MM.1R) cells, most importantly its main upstream signaling pathway is through the PI3k/Akt/NF-κB pathway and is also associated with MAPK pathway, via mitochondrial apoptotic signaling and is also associated with the caspase and Bcl-2 family members. Moreover, TPL was able to enhance the activities of dexamethasone or bortezomib/PS-341 in multiple myeloma cell lines. Collectively, these findings provide the framework for a clinical evaluation of TPL, either alone or in combination with dexamethasone or bortezomib/PS-341, to overcome drug resistance and improve outcome for patients with this universially fatal hematological malignancy.

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Copy and paste a formatted citation
Spandidos Publications style
Yang M, Huang J, Pan H and Jin J: Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-κB pathways in human multiple myeloma cells. Int J Mol Med 22: 489-496, 2008.
APA
Yang, M., Huang, J., Pan, H., & Jin, J. (2008). Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-κB pathways in human multiple myeloma cells. International Journal of Molecular Medicine, 22, 489-496. https://doi.org/10.3892/ijmm_00000047
MLA
Yang, M., Huang, J., Pan, H., Jin, J."Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-κB pathways in human multiple myeloma cells". International Journal of Molecular Medicine 22.4 (2008): 489-496.
Chicago
Yang, M., Huang, J., Pan, H., Jin, J."Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-κB pathways in human multiple myeloma cells". International Journal of Molecular Medicine 22, no. 4 (2008): 489-496. https://doi.org/10.3892/ijmm_00000047
Copy and paste a formatted citation
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Spandidos Publications style
Yang M, Huang J, Pan H and Jin J: Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-κB pathways in human multiple myeloma cells. Int J Mol Med 22: 489-496, 2008.
APA
Yang, M., Huang, J., Pan, H., & Jin, J. (2008). Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-κB pathways in human multiple myeloma cells. International Journal of Molecular Medicine, 22, 489-496. https://doi.org/10.3892/ijmm_00000047
MLA
Yang, M., Huang, J., Pan, H., Jin, J."Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-κB pathways in human multiple myeloma cells". International Journal of Molecular Medicine 22.4 (2008): 489-496.
Chicago
Yang, M., Huang, J., Pan, H., Jin, J."Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-κB pathways in human multiple myeloma cells". International Journal of Molecular Medicine 22, no. 4 (2008): 489-496. https://doi.org/10.3892/ijmm_00000047
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