Inhibitory action of roxithromycin on histamine release and prostaglandin D2 production from β-defensin 2-stimulated mast cells

Kase,Kaori; Hua,Jian; Yokoi,Hidenori; Ikeda,Katsuhisa; Nagaoka,Isao

doi:10.3892/ijmm_00000136

March 2009 Volume 23 Issue 3

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March 2009 Volume 23 Issue 3

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Article

Inhibitory action of roxithromycin on histamine release and prostaglandin D2 production from β-defensin 2-stimulated mast cells

Authors:
- Kaori Kase
- Jian Hua
- Hidenori Yokoi
- Katsuhisa Ikeda
- Isao Nagaoka
View Affiliations / Copyright

Affiliations: Department of Otorhinolaryngology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan
Pages: 337-340
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Published online on: March 1, 2009

https://doi.org/10.3892/ijmm_00000136
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Abstract

The long-term, low-dose therapy with the 14-membered macrolides is well known to be effective for treatment of chronic airway inflammation. Although the mode of macrolides on neutrophils, monocytes, and epithelial cells has been investigated, the effect of macrolides on mast cell function is sparsely reported on. We first examined the effect of roxithromycin (RXM) on mast cell functions activated by human β-defensin-2 (hBD-2). In this study, histamine release, prostaglandin D2 (PGD2) production, and intracellular Ca2+ concentration ([Ca2+]i) were measured in the absence and presence of RXM, using rat peritoneal mast cells stimulated with hBD-2. RXM, at doses of 12.5 and 25 µg/ml, significantly inhibited the histamine release from mast cells (p<0.05). In addition, PGD2 production induced by hBD-2 was significantly reduced by RXM at 6.25 (p<0.05) and 12.5 µg/ml (p<0.01). Furthermore, the hBD-2-induced increase of [Ca2+]i in mast cells was inhibited by 6.25 and 12.5 µg/ml of RXM (p<0.05). The present findings suggest that RXM modulates mast cell activation induced by hBD-2 via a Ca2+ signal pathway, thereby possibly alleviating chronic airway inflammation.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Inhibitory action of roxithromycin on histamine release and prostaglandin D2 production from β-defensin 2-stimulated mast cells

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