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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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March 2009 Volume 23 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein

  • Authors:
    • Karin Hoppe-Seyler
    • Kilian Weigand
    • claudia lohrey
    • Felix Hoppe-Seyler
    • Peter Sauer

  • View Affiliations / Copyright

    Affiliations: Molecular Therapy of Virus-Associated Cancers (F065), German Cancer Research Center, D-69120 Heidelberg, Germany. k.hoppe-seyler@dkfz.de
  • Pages: 415-420
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/ijmm_00000146
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Abstract

The malononitrilamide FK778 is a novel immunosuppressive agent with antiproliferative activities. To gain insight into the molecular mechanism of FK778-mediated growth inhibition, we analyzed cells which differ in their p53 status and functionality of retinoblastoma protein (pRb). FK778 acted as a broad inhibitor of cell proliferation independent of the p53 or pRb status. However, the mechanism of FK778-mediated growth inhibition differed, leading either to cell cycle arrest in G1, or cell accumulation in S phase. This differential response was linked to the phosphorylation status of pRb. In addition, since FK778 was reported to exhibit antiviral activities, we analyzed the effect of FK778 on the growth stimulatory human papillomavirus (HPV)-16 and -18 E7 genes. Although growth of HPV-positive cells was strongly inhibited by FK778, we did not observe significant effects on viral E7 expression, indicating that the antiproliferative effect is not linked to an antiviral activity of FK778.

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Copy and paste a formatted citation
Spandidos Publications style
Hoppe-Seyler K, Weigand K, lohrey c, Hoppe-Seyler F and Sauer P: Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein. Int J Mol Med 23: 415-420, 2009.
APA
Hoppe-Seyler, K., Weigand, K., lohrey, c., Hoppe-Seyler, F., & Sauer, P. (2009). Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein. International Journal of Molecular Medicine, 23, 415-420. https://doi.org/10.3892/ijmm_00000146
MLA
Hoppe-Seyler, K., Weigand, K., lohrey, c., Hoppe-Seyler, F., Sauer, P."Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein". International Journal of Molecular Medicine 23.3 (2009): 415-420.
Chicago
Hoppe-Seyler, K., Weigand, K., lohrey, c., Hoppe-Seyler, F., Sauer, P."Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein". International Journal of Molecular Medicine 23, no. 3 (2009): 415-420. https://doi.org/10.3892/ijmm_00000146
Copy and paste a formatted citation
x
Spandidos Publications style
Hoppe-Seyler K, Weigand K, lohrey c, Hoppe-Seyler F and Sauer P: Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein. Int J Mol Med 23: 415-420, 2009.
APA
Hoppe-Seyler, K., Weigand, K., lohrey, c., Hoppe-Seyler, F., & Sauer, P. (2009). Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein. International Journal of Molecular Medicine, 23, 415-420. https://doi.org/10.3892/ijmm_00000146
MLA
Hoppe-Seyler, K., Weigand, K., lohrey, c., Hoppe-Seyler, F., Sauer, P."Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein". International Journal of Molecular Medicine 23.3 (2009): 415-420.
Chicago
Hoppe-Seyler, K., Weigand, K., lohrey, c., Hoppe-Seyler, F., Sauer, P."Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein". International Journal of Molecular Medicine 23, no. 3 (2009): 415-420. https://doi.org/10.3892/ijmm_00000146
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