Association between estrogen receptor α polymorphisms and equol production, and its relation to bone mass

  • Authors:
    • Hironobu Katsuyama
    • Masayuki Arii
    • Masafumi Tomita
    • Kazuo Hidaka
    • Yoko Watanabe
    • Yoshie Tamechika
    • Toshiko Okuyama
    • Shigeko Fushimi
    • Noriko Maeda
    • Tsutomu Higashimura
    • Masao Fukunaga
    • Kiyofumi Saijoh
  • View Affiliations

  • Published online on: June 1, 2009     https://doi.org/10.3892/ijmm_00000194
  • Pages: 793-798
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Abstract

To investigate the relationship between estrogen receptor polymorphisms and equol production and its effect on bone turnover, 139 workers (mean age 38.3±11.1 years) in Japan were recruited. Bone mineral density (BMD), bone turnover markers, and serum equol were measured at a health examination. DNA samples were prepared to detect the estrogen receptor α (ERα) polymorphism and were digested by PvuII. The number of equol producers was 57. No statistically significant differences were observed in bone mineral density and bone turnover markers between each ERα polymorphism and equol production. Since the adjusted odds ratio indicated that interaction itself decreased the risk of osteosono-assessment index (OSI) reduction using logistic regression analysis, further analysis was performed divided by each ERα polymorphism. Although the crude odds ratio showed no relationship between equol producers and non-producers, the adjusted odds ratio showed that equol producers with ERα pp had a significantly decreased risk of OSI reduction. Although this study was cross-sectional, both equol production and ERα polymorphism are closely associated with each other in relation to BMD.

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June 2009
Volume 23 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Katsuyama H, Arii M, Tomita M, Hidaka K, Watanabe Y, Tamechika Y, Okuyama T, Fushimi S, Maeda N, Higashimura T, Higashimura T, et al: Association between estrogen receptor α polymorphisms and equol production, and its relation to bone mass. Int J Mol Med 23: 793-798, 2009
APA
Katsuyama, H., Arii, M., Tomita, M., Hidaka, K., Watanabe, Y., Tamechika, Y. ... Saijoh, K. (2009). Association between estrogen receptor α polymorphisms and equol production, and its relation to bone mass. International Journal of Molecular Medicine, 23, 793-798. https://doi.org/10.3892/ijmm_00000194
MLA
Katsuyama, H., Arii, M., Tomita, M., Hidaka, K., Watanabe, Y., Tamechika, Y., Okuyama, T., Fushimi, S., Maeda, N., Higashimura, T., Fukunaga, M., Saijoh, K."Association between estrogen receptor α polymorphisms and equol production, and its relation to bone mass". International Journal of Molecular Medicine 23.6 (2009): 793-798.
Chicago
Katsuyama, H., Arii, M., Tomita, M., Hidaka, K., Watanabe, Y., Tamechika, Y., Okuyama, T., Fushimi, S., Maeda, N., Higashimura, T., Fukunaga, M., Saijoh, K."Association between estrogen receptor α polymorphisms and equol production, and its relation to bone mass". International Journal of Molecular Medicine 23, no. 6 (2009): 793-798. https://doi.org/10.3892/ijmm_00000194