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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2009 Volume 24 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2009 Volume 24 Issue 1

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Article

PPARδ mediates IL15 metabolic actions in myotubes: Effects of hyperthermia

  • Authors:
    • Gemma Fuster
    • Sílvia Busquets
    • Maite Figueras
    • Elisabet Ametller
    • Cibely Cristine Fontes de Oliveira
    • Mireia Oliván
    • Paul A. Grimaldi
    • Josep M. Argilés
    • Francisco J. López-Soriano

  • View Affiliations / Copyright

    Affiliations: Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645; Institut de Biomedicina de la Universitat de Barcelona (IBUB), 08028 Barcelona, Spain
  • Pages: 63-68
    |
    Published online on: July 1, 2009
       https://doi.org/10.3892/ijmm_00000207
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Abstract

C2C12 cells exposed to hyperthermia (41°C) experienced an increase in both protein synthesis and degradation. The addition of IL15 under hyperthermic conditions resulted in an important increase in protein synthesis with no changes in protein degradation, except when cells overexpressed PPARδ. The PPARδ agonist GW501516 exerted similar effects on protein synthesis to IL15. Expression of a mutant dominant negative form of PPARδ prevented the effect of the cytokine on protein synthesis, suggesting that this transcription factor is involved in the anabolic action of IL15. The present study also suggests that the effects of IL15 on lipid oxidation could be mediated by PPARδ.

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Copy and paste a formatted citation
Spandidos Publications style
Fuster G, Busquets S, Figueras M, Ametller E, Fontes de Oliveira CC, Oliván M, Grimaldi PA, Argilés JM and López-Soriano FJ: PPARδ mediates IL15 metabolic actions in myotubes: Effects of hyperthermia. Int J Mol Med 24: 63-68, 2009.
APA
Fuster, G., Busquets, S., Figueras, M., Ametller, E., Fontes de Oliveira, C.C., Oliván, M. ... López-Soriano, F.J. (2009). PPARδ mediates IL15 metabolic actions in myotubes: Effects of hyperthermia. International Journal of Molecular Medicine, 24, 63-68. https://doi.org/10.3892/ijmm_00000207
MLA
Fuster, G., Busquets, S., Figueras, M., Ametller, E., Fontes de Oliveira, C. C., Oliván, M., Grimaldi, P. A., Argilés, J. M., López-Soriano, F. J."PPARδ mediates IL15 metabolic actions in myotubes: Effects of hyperthermia". International Journal of Molecular Medicine 24.1 (2009): 63-68.
Chicago
Fuster, G., Busquets, S., Figueras, M., Ametller, E., Fontes de Oliveira, C. C., Oliván, M., Grimaldi, P. A., Argilés, J. M., López-Soriano, F. J."PPARδ mediates IL15 metabolic actions in myotubes: Effects of hyperthermia". International Journal of Molecular Medicine 24, no. 1 (2009): 63-68. https://doi.org/10.3892/ijmm_00000207
Copy and paste a formatted citation
x
Spandidos Publications style
Fuster G, Busquets S, Figueras M, Ametller E, Fontes de Oliveira CC, Oliván M, Grimaldi PA, Argilés JM and López-Soriano FJ: PPARδ mediates IL15 metabolic actions in myotubes: Effects of hyperthermia. Int J Mol Med 24: 63-68, 2009.
APA
Fuster, G., Busquets, S., Figueras, M., Ametller, E., Fontes de Oliveira, C.C., Oliván, M. ... López-Soriano, F.J. (2009). PPARδ mediates IL15 metabolic actions in myotubes: Effects of hyperthermia. International Journal of Molecular Medicine, 24, 63-68. https://doi.org/10.3892/ijmm_00000207
MLA
Fuster, G., Busquets, S., Figueras, M., Ametller, E., Fontes de Oliveira, C. C., Oliván, M., Grimaldi, P. A., Argilés, J. M., López-Soriano, F. J."PPARδ mediates IL15 metabolic actions in myotubes: Effects of hyperthermia". International Journal of Molecular Medicine 24.1 (2009): 63-68.
Chicago
Fuster, G., Busquets, S., Figueras, M., Ametller, E., Fontes de Oliveira, C. C., Oliván, M., Grimaldi, P. A., Argilés, J. M., López-Soriano, F. J."PPARδ mediates IL15 metabolic actions in myotubes: Effects of hyperthermia". International Journal of Molecular Medicine 24, no. 1 (2009): 63-68. https://doi.org/10.3892/ijmm_00000207
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