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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September 2009 Volume 24 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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September 2009 Volume 24 Issue 3

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Review

Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses (Review)

  • Authors:
    • George Vardatsikos
    • Mohamad Z. Mehdi
    • Ashok K. Srivastava

  • View Affiliations / Copyright

    Affiliations: Laboratory of Cell Signaling, Montreal Diabetes Research Center, Research Center-Centre Hospitalier de l'Université de Montréal (CRCHUM) and Department of Medicine, Université de Montréal, Montréal, Québec, H1W 4A4, Canada
  • Pages: 303-309
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/ijmm_00000233
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Abstract

Over the last several decades, a large body of evidence has accumulated to suggest that organo-vanadium compounds (OVC) are more potent than inorganic vanadium salts in regulating hyperglycemia and insulin-resistance in rodent models of both type I and type II diabetes. Among these OVC, vanadium (IV) oxo bis(maltolato) (BMOV) was the first to be investigated for its higher potency over inorganic vanadium salts in eliciting insulin-like properties in both in vitro and in vivo systems. While the precise molecular mechanism by which BMOV exerts its insulin-mimetic effects remains poorly defined, studies have shown that BMOV is a potent activator of several key components of the insulin signaling pathways, such as phosphatidyl-inositol 3-kinase (PI3-K), and its downstream effector, protein kinase B (PKB). In addition, BMOV-induced phosphorylation of PKB has also been associated with the enhanced phosphorylation of glycogen synthase kinase-3 (GSK-3) and forkhead box protein 1 (FOXO1). Since PKB is instrumental in mediating the effects of insulin on glucose transport, glycogen synthesis and gluconeogenesis, it is reasonable to suggest that activation of this pathway by BMOV serves as a mechanism for its insulin-like effects.

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Copy and paste a formatted citation
Spandidos Publications style
Vardatsikos G, Mehdi MZ and Srivastava AK: Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses (Review). Int J Mol Med 24: 303-309, 2009.
APA
Vardatsikos, G., Mehdi, M.Z., & Srivastava, A.K. (2009). Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses (Review). International Journal of Molecular Medicine, 24, 303-309. https://doi.org/10.3892/ijmm_00000233
MLA
Vardatsikos, G., Mehdi, M. Z., Srivastava, A. K."Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses (Review)". International Journal of Molecular Medicine 24.3 (2009): 303-309.
Chicago
Vardatsikos, G., Mehdi, M. Z., Srivastava, A. K."Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses (Review)". International Journal of Molecular Medicine 24, no. 3 (2009): 303-309. https://doi.org/10.3892/ijmm_00000233
Copy and paste a formatted citation
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Spandidos Publications style
Vardatsikos G, Mehdi MZ and Srivastava AK: Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses (Review). Int J Mol Med 24: 303-309, 2009.
APA
Vardatsikos, G., Mehdi, M.Z., & Srivastava, A.K. (2009). Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses (Review). International Journal of Molecular Medicine, 24, 303-309. https://doi.org/10.3892/ijmm_00000233
MLA
Vardatsikos, G., Mehdi, M. Z., Srivastava, A. K."Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses (Review)". International Journal of Molecular Medicine 24.3 (2009): 303-309.
Chicago
Vardatsikos, G., Mehdi, M. Z., Srivastava, A. K."Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses (Review)". International Journal of Molecular Medicine 24, no. 3 (2009): 303-309. https://doi.org/10.3892/ijmm_00000233
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