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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September 2009 Volume 24 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2009 Volume 24 Issue 3

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Article

The effect of cadmium on brain cells in culture

  • Authors:
    • Christian Gerspacher
    • Urs Scheuber
    • Gabriella Schiera
    • Patrizia Proia
    • Daniel Gygax
    • Italia Di Liegro

  • View Affiliations / Copyright

    Affiliations: Dipartimento di Biologia Cellulare e dello Sviluppo, Università degli Studi di Palermo, Palermo, Italy
  • Pages: 311-318
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/ijmm_00000234
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Abstract

Cadmium is a long-living heavy metal, abundantly present in the environment, which accumulates in the body. In this study, we investigated the effects of cadmium on the expression of molecular chaperones, and of certain cell-specific proteins, in a variety of brain cell types in culture, namely primary cultures of rat cortical neurons and astrocytes, a brain capillary endothelial cell line (RB4E.B cells), and pheochromocytoma cells (PC12), induced or not to differentiate by NGF treatment. The metal induces a dose-dependent increase of Hsp70 in all cell types. Responses to the metal are cell-specific in the case of Hsc70 and Hsp90: i) in astrocytes, as well as in PC12 cells, cadmium has no significant effect; ii) in endothelial cells, an increase of both proteins is clearly observable from 20 µM cadmium; iii) both Hsp90 and Hsc70 decrease in neurons treated with high doses of cadmium. Damage to the cytoskeleton in treated cells was also evident. Finally, we report that the metal at high doses induces a decrease of PIPPin (also known as CSD-C2), a putative RNA-binding protein highly expressed in neurons and probably involved in the regulation of histone replacement variant expression.

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Copy and paste a formatted citation
Spandidos Publications style
Gerspacher C, Scheuber U, Schiera G, Proia P, Gygax D and Di Liegro I: The effect of cadmium on brain cells in culture. Int J Mol Med 24: 311-318, 2009.
APA
Gerspacher, C., Scheuber, U., Schiera, G., Proia, P., Gygax, D., & Di Liegro, I. (2009). The effect of cadmium on brain cells in culture. International Journal of Molecular Medicine, 24, 311-318. https://doi.org/10.3892/ijmm_00000234
MLA
Gerspacher, C., Scheuber, U., Schiera, G., Proia, P., Gygax, D., Di Liegro, I."The effect of cadmium on brain cells in culture". International Journal of Molecular Medicine 24.3 (2009): 311-318.
Chicago
Gerspacher, C., Scheuber, U., Schiera, G., Proia, P., Gygax, D., Di Liegro, I."The effect of cadmium on brain cells in culture". International Journal of Molecular Medicine 24, no. 3 (2009): 311-318. https://doi.org/10.3892/ijmm_00000234
Copy and paste a formatted citation
x
Spandidos Publications style
Gerspacher C, Scheuber U, Schiera G, Proia P, Gygax D and Di Liegro I: The effect of cadmium on brain cells in culture. Int J Mol Med 24: 311-318, 2009.
APA
Gerspacher, C., Scheuber, U., Schiera, G., Proia, P., Gygax, D., & Di Liegro, I. (2009). The effect of cadmium on brain cells in culture. International Journal of Molecular Medicine, 24, 311-318. https://doi.org/10.3892/ijmm_00000234
MLA
Gerspacher, C., Scheuber, U., Schiera, G., Proia, P., Gygax, D., Di Liegro, I."The effect of cadmium on brain cells in culture". International Journal of Molecular Medicine 24.3 (2009): 311-318.
Chicago
Gerspacher, C., Scheuber, U., Schiera, G., Proia, P., Gygax, D., Di Liegro, I."The effect of cadmium on brain cells in culture". International Journal of Molecular Medicine 24, no. 3 (2009): 311-318. https://doi.org/10.3892/ijmm_00000234
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