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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2009 Volume 24 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2009 Volume 24 Issue 5

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Article

The bone anabolic carotenoid β-cryptoxanthin enhances transforming growth factor-β1-induced SMAD activation in MC3T3 preosteoblasts

  • Authors:
    • Masayoshi Yamaguchi
    • M. Neale Weitzmann

  • View Affiliations / Copyright

    Affiliations: Division of Endocrinology and Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, 1329 WMRB, Atlanta, GA 30322-0001, USA. yamamasa1155@yahoo.co.jp
  • Pages: 671-675
    |
    Published online on: November 1, 2009
       https://doi.org/10.3892/ijmm_00000278
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Abstract

The xanthophyll β-cryptoxanthin is a member of the carotenoid family of plant-derived pigments endowed with anti-osteoporotic properties in vivo. β-cryptoxanthin was demonstrated to stimulate osteoblastic bone formation and simultaneously repress osteoclastic bone resorption in vitro. However, the mechanisms of action remain to be elucidated. The SMAD signal transduction pathway is established to play a critical role in osteoblast lineage commitment and differentiation. In this study we used transient transfection assays of a SMAD luciferase reporter to investigate whether β-cryptoxanthin regulates SMAD activation in MC3T3 pre-osteoblastic cells. β-cryptoxanthin did not stimulate basal SMAD activity but amplified transforming growth factor (TGF)-β1-induced SMAD activation. Interestingly, β-cryptoxanthin did not affect bone morphogenetic protein-2 (BMP-2)-induced SMAD activation in osteoblastic cells, suggesting specificity of action on the TGF-β1 pathway. This study suggests that the carotenoid β-cryptoxanthin may promote osteoblast differentiation and activity by amplifying TGF-β1-induced lineage commitment of osteoblast precursors.

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Copy and paste a formatted citation
Spandidos Publications style
Yamaguchi M and Weitzmann MN: The bone anabolic carotenoid β-cryptoxanthin enhances transforming growth factor-β1-induced SMAD activation in MC3T3 preosteoblasts. Int J Mol Med 24: 671-675, 2009.
APA
Yamaguchi, M., & Weitzmann, M.N. (2009). The bone anabolic carotenoid β-cryptoxanthin enhances transforming growth factor-β1-induced SMAD activation in MC3T3 preosteoblasts. International Journal of Molecular Medicine, 24, 671-675. https://doi.org/10.3892/ijmm_00000278
MLA
Yamaguchi, M., Weitzmann, M. N."The bone anabolic carotenoid β-cryptoxanthin enhances transforming growth factor-β1-induced SMAD activation in MC3T3 preosteoblasts". International Journal of Molecular Medicine 24.5 (2009): 671-675.
Chicago
Yamaguchi, M., Weitzmann, M. N."The bone anabolic carotenoid β-cryptoxanthin enhances transforming growth factor-β1-induced SMAD activation in MC3T3 preosteoblasts". International Journal of Molecular Medicine 24, no. 5 (2009): 671-675. https://doi.org/10.3892/ijmm_00000278
Copy and paste a formatted citation
x
Spandidos Publications style
Yamaguchi M and Weitzmann MN: The bone anabolic carotenoid β-cryptoxanthin enhances transforming growth factor-β1-induced SMAD activation in MC3T3 preosteoblasts. Int J Mol Med 24: 671-675, 2009.
APA
Yamaguchi, M., & Weitzmann, M.N. (2009). The bone anabolic carotenoid β-cryptoxanthin enhances transforming growth factor-β1-induced SMAD activation in MC3T3 preosteoblasts. International Journal of Molecular Medicine, 24, 671-675. https://doi.org/10.3892/ijmm_00000278
MLA
Yamaguchi, M., Weitzmann, M. N."The bone anabolic carotenoid β-cryptoxanthin enhances transforming growth factor-β1-induced SMAD activation in MC3T3 preosteoblasts". International Journal of Molecular Medicine 24.5 (2009): 671-675.
Chicago
Yamaguchi, M., Weitzmann, M. N."The bone anabolic carotenoid β-cryptoxanthin enhances transforming growth factor-β1-induced SMAD activation in MC3T3 preosteoblasts". International Journal of Molecular Medicine 24, no. 5 (2009): 671-675. https://doi.org/10.3892/ijmm_00000278
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