Antitumor activity of asukamycin, a secondary metabolite from the actinomycete bacterium Streptomyces nodosus subspecies asukaensis

  • Authors:
    • Paul R. Shipley
    • Caitlin C.A. Donnelly
    • Cuong H. Le
    • Ashley D. Bernauer
    • Andis Klegeris
  • View Affiliations

  • Published online on: November 1, 2009     https://doi.org/10.3892/ijmm_00000283
  • Pages: 711-715
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Abstract

Asukamycin, a manumycin-type metabolite, was isolated by a rapid and easily scalable purification scheme. Thus far, studies on the biological activity of asukamycin have been limited to its role as an antibacterial and antifungal agent. By using five different tumor cell lines we demonstrate antineoplastic activity of asukamycin. It inhibited cell growth at concentrations similar to other members of the manumycin family (IC50 1-5 µM). Cytotoxicity of asukamycin was accompanied by activation of caspases 8 and 3 and was diminished by SB 202190, a specific p38 mitogen-activated protein kinase (MAPK) inhibitor. These data, in combination with earlier observations showing its low in vivo toxicity, indicate that further studies on the potential antitumor activity of asukamycin are warranted.

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November 2009
Volume 24 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Shipley PR, Donnelly CC, Le CH, Bernauer AD and Klegeris A: Antitumor activity of asukamycin, a secondary metabolite from the actinomycete bacterium Streptomyces nodosus subspecies asukaensis. Int J Mol Med 24: 711-715, 2009
APA
Shipley, P.R., Donnelly, C.C., Le, C.H., Bernauer, A.D., & Klegeris, A. (2009). Antitumor activity of asukamycin, a secondary metabolite from the actinomycete bacterium Streptomyces nodosus subspecies asukaensis. International Journal of Molecular Medicine, 24, 711-715. https://doi.org/10.3892/ijmm_00000283
MLA
Shipley, P. R., Donnelly, C. C., Le, C. H., Bernauer, A. D., Klegeris, A."Antitumor activity of asukamycin, a secondary metabolite from the actinomycete bacterium Streptomyces nodosus subspecies asukaensis". International Journal of Molecular Medicine 24.5 (2009): 711-715.
Chicago
Shipley, P. R., Donnelly, C. C., Le, C. H., Bernauer, A. D., Klegeris, A."Antitumor activity of asukamycin, a secondary metabolite from the actinomycete bacterium Streptomyces nodosus subspecies asukaensis". International Journal of Molecular Medicine 24, no. 5 (2009): 711-715. https://doi.org/10.3892/ijmm_00000283