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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January 2010 Volume 25 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2010 Volume 25 Issue 1

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Article

Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation

  • Authors:
    • Takeshi Kuribayashi
    • Maki Ohara
    • Sakura Sora
    • Nobuo Kubota

  • View Affiliations / Copyright

    Affiliations: Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki 300-0394, Japan
  • Pages: 25-29
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/ijmm_00000309
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Abstract

A group of histone deacetylase (HDAC) inhibitors has been shown to suppress the growth of a variety of human tumor lines in vitro and in vivo and they are among the most promising candidates for anti-cancer therapeutic agents. We investigated the ability of scriptaid, a novel HDAC inhibitor and trichostatin A (TSA) to enhance cell killing by radiation in radioresistant SQ-20B cells derived from human head and neck squamous carcinoma. SQ-20B cells were treated with scriptaid or TSA in combination with radiation. Cell survival was determined by a colony formation assay and protein levels were examined by Western blotting. DNA double strand breaks were measured by a γ-H2AX focus assay. Radiosensitization was observed for SQ-20B cells incubated with scriptaid at 5 µM or TSA at 0.1 µM for 24 h. Radiosensitization by scriptaid was accompanied by a prolonged retention of γ-H2AX foci, suggesting that the enhancement of radiation cell killing by scriptaid involved inhibition of DNA double strand break repair. In addition, treatment with scriptaid suppressed expression of Ku80, but not Ku70. Scriptaid may be a useful radiosensitizer in the treatment of radioresistant human carcinomas.

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Copy and paste a formatted citation
Spandidos Publications style
Kuribayashi T, Ohara M, Sora S and Kubota N: Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation. Int J Mol Med 25: 25-29, 2010.
APA
Kuribayashi, T., Ohara, M., Sora, S., & Kubota, N. (2010). Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation. International Journal of Molecular Medicine, 25, 25-29. https://doi.org/10.3892/ijmm_00000309
MLA
Kuribayashi, T., Ohara, M., Sora, S., Kubota, N."Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation". International Journal of Molecular Medicine 25.1 (2010): 25-29.
Chicago
Kuribayashi, T., Ohara, M., Sora, S., Kubota, N."Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation". International Journal of Molecular Medicine 25, no. 1 (2010): 25-29. https://doi.org/10.3892/ijmm_00000309
Copy and paste a formatted citation
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Spandidos Publications style
Kuribayashi T, Ohara M, Sora S and Kubota N: Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation. Int J Mol Med 25: 25-29, 2010.
APA
Kuribayashi, T., Ohara, M., Sora, S., & Kubota, N. (2010). Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation. International Journal of Molecular Medicine, 25, 25-29. https://doi.org/10.3892/ijmm_00000309
MLA
Kuribayashi, T., Ohara, M., Sora, S., Kubota, N."Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation". International Journal of Molecular Medicine 25.1 (2010): 25-29.
Chicago
Kuribayashi, T., Ohara, M., Sora, S., Kubota, N."Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation". International Journal of Molecular Medicine 25, no. 1 (2010): 25-29. https://doi.org/10.3892/ijmm_00000309
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