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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January 2010 Volume 25 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2010 Volume 25 Issue 1

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Article

Inhibiting tumor growth of colorectal cancer by blocking the expression of vascular endothelial growth factor receptor 3 using interference vector-based RNA interference

  • Authors:
    • Zhicheng Lui
    • Qiang Ma
    • Xianghui Wang
    • Youcheng Zhang

  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, P.R. China
  • Pages: 59-64
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/ijmm_00000313
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Abstract

Many reports show that vascular endothelial growth factor receptor 3 (VEGFR3) plays an essential role in tumor metastasis and is a promising target for cancer therapy. The present study was designed to determine the role of VEGFR3 in tumor growth using RNA interference (RNAi) technology. Three small interfering RNA (siRNA) sequences for the VEGFR3 gene were cloned into expression plasmids (pSUPER) and transfected into human colorectal carcinoma (CRC) LoVo cells. Stable transfection of these plasmids decreased VEGFR3 protein expression, leading to the potent suppression of tumor cell proliferation and lymphangiogenesis in vitro. Furthermore, we selected the most effective silenced expressor vector and injected it and pSUPER vector into a tumor xenograft model in nude mice. The tumor growth of LoVo cells expressing VEGFR3 siRNA were significantly inhibited compared with cells transfected with control vector alone. Immunohistochemical analyses of tumor sections revealed a decreased vessel density and decreased VEGFR3 expression in animals when siRNA against VEGFR3 was expressed. These results showed that RNAi of VEGFR3 is an effective tool to reduce lymphangiogenesis in CRC.

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Copy and paste a formatted citation
Spandidos Publications style
Lui Z, Ma Q, Wang X and Zhang Y: Inhibiting tumor growth of colorectal cancer by blocking the expression of vascular endothelial growth factor receptor 3 using interference vector-based RNA interference. Int J Mol Med 25: 59-64, 2010.
APA
Lui, Z., Ma, Q., Wang, X., & Zhang, Y. (2010). Inhibiting tumor growth of colorectal cancer by blocking the expression of vascular endothelial growth factor receptor 3 using interference vector-based RNA interference. International Journal of Molecular Medicine, 25, 59-64. https://doi.org/10.3892/ijmm_00000313
MLA
Lui, Z., Ma, Q., Wang, X., Zhang, Y."Inhibiting tumor growth of colorectal cancer by blocking the expression of vascular endothelial growth factor receptor 3 using interference vector-based RNA interference". International Journal of Molecular Medicine 25.1 (2010): 59-64.
Chicago
Lui, Z., Ma, Q., Wang, X., Zhang, Y."Inhibiting tumor growth of colorectal cancer by blocking the expression of vascular endothelial growth factor receptor 3 using interference vector-based RNA interference". International Journal of Molecular Medicine 25, no. 1 (2010): 59-64. https://doi.org/10.3892/ijmm_00000313
Copy and paste a formatted citation
x
Spandidos Publications style
Lui Z, Ma Q, Wang X and Zhang Y: Inhibiting tumor growth of colorectal cancer by blocking the expression of vascular endothelial growth factor receptor 3 using interference vector-based RNA interference. Int J Mol Med 25: 59-64, 2010.
APA
Lui, Z., Ma, Q., Wang, X., & Zhang, Y. (2010). Inhibiting tumor growth of colorectal cancer by blocking the expression of vascular endothelial growth factor receptor 3 using interference vector-based RNA interference. International Journal of Molecular Medicine, 25, 59-64. https://doi.org/10.3892/ijmm_00000313
MLA
Lui, Z., Ma, Q., Wang, X., Zhang, Y."Inhibiting tumor growth of colorectal cancer by blocking the expression of vascular endothelial growth factor receptor 3 using interference vector-based RNA interference". International Journal of Molecular Medicine 25.1 (2010): 59-64.
Chicago
Lui, Z., Ma, Q., Wang, X., Zhang, Y."Inhibiting tumor growth of colorectal cancer by blocking the expression of vascular endothelial growth factor receptor 3 using interference vector-based RNA interference". International Journal of Molecular Medicine 25, no. 1 (2010): 59-64. https://doi.org/10.3892/ijmm_00000313
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