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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2010 Volume 25 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Partially purified Asiasari radix inhibits melanogenesis through extracellular signal-regulated kinase signaling in B16F10 cells

  • Authors:
    • Ji-Yeon Jang
    • Jun-Hyuk Lee
    • Hwa-Kyoung Shin
    • Yung-Hyun Choi
    • Jae-Dong Lee
    • Byung-Tae Choi

  • View Affiliations / Copyright

    Affiliations: Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University, Yangsan 626-770, Korea
  • Pages: 287-292
    |
    Published online on: February 1, 2010
       https://doi.org/10.3892/ijmm_00000343
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Abstract

The active fraction of the extract of Asiasari radix, the 60% methanol chromatographic fraction from the ethyl acetate layer (PPAR), was used to investigate the melanogenesis signal pathway in B16F10 melanoma cells. PPAR led to significantly decreased melanin synthesis and tyrosinase activity in a dose-dependent manner. PPAR also reduced the expression of melanogenesis-related proteins including microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein (TRP)s while down-regulating the expression of mRNA of MITF and tyrosinase. Melanogenesis-regulating signals, such as mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK), phosphatidylinositol 3-kinase (PI3K)/Akt and p38 mitogen-activated protein kinase (MAPK) were evaluated, and ERK was activated by PPAR. The selective inhibitor of MEK/ERK, PD98059, abrogated all suppressive activities of PPAR on melanin biosynthesis, tyrosinase activation and expression of melanogenesis-related proteins. These results suggest that ERK activation by PPAR contributes to reduced melanin synthesis via ERK signal pathway-mediated suppression of MITF and its downstream signal pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Jang J, Lee J, Shin H, Choi Y, Lee J and Choi B: Partially purified Asiasari radix inhibits melanogenesis through extracellular signal-regulated kinase signaling in B16F10 cells. Int J Mol Med 25: 287-292, 2010.
APA
Jang, J., Lee, J., Shin, H., Choi, Y., Lee, J., & Choi, B. (2010). Partially purified Asiasari radix inhibits melanogenesis through extracellular signal-regulated kinase signaling in B16F10 cells. International Journal of Molecular Medicine, 25, 287-292. https://doi.org/10.3892/ijmm_00000343
MLA
Jang, J., Lee, J., Shin, H., Choi, Y., Lee, J., Choi, B."Partially purified Asiasari radix inhibits melanogenesis through extracellular signal-regulated kinase signaling in B16F10 cells". International Journal of Molecular Medicine 25.2 (2010): 287-292.
Chicago
Jang, J., Lee, J., Shin, H., Choi, Y., Lee, J., Choi, B."Partially purified Asiasari radix inhibits melanogenesis through extracellular signal-regulated kinase signaling in B16F10 cells". International Journal of Molecular Medicine 25, no. 2 (2010): 287-292. https://doi.org/10.3892/ijmm_00000343
Copy and paste a formatted citation
x
Spandidos Publications style
Jang J, Lee J, Shin H, Choi Y, Lee J and Choi B: Partially purified Asiasari radix inhibits melanogenesis through extracellular signal-regulated kinase signaling in B16F10 cells. Int J Mol Med 25: 287-292, 2010.
APA
Jang, J., Lee, J., Shin, H., Choi, Y., Lee, J., & Choi, B. (2010). Partially purified Asiasari radix inhibits melanogenesis through extracellular signal-regulated kinase signaling in B16F10 cells. International Journal of Molecular Medicine, 25, 287-292. https://doi.org/10.3892/ijmm_00000343
MLA
Jang, J., Lee, J., Shin, H., Choi, Y., Lee, J., Choi, B."Partially purified Asiasari radix inhibits melanogenesis through extracellular signal-regulated kinase signaling in B16F10 cells". International Journal of Molecular Medicine 25.2 (2010): 287-292.
Chicago
Jang, J., Lee, J., Shin, H., Choi, Y., Lee, J., Choi, B."Partially purified Asiasari radix inhibits melanogenesis through extracellular signal-regulated kinase signaling in B16F10 cells". International Journal of Molecular Medicine 25, no. 2 (2010): 287-292. https://doi.org/10.3892/ijmm_00000343
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