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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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March 2010 Volume 25 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March 2010 Volume 25 Issue 3

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Review

Dual role of complement in tumour growth and metastasis (Review)

  • Authors:
    • Cordula Stover
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    Affiliations: Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, UK. cms13@le.ac.uk
  • Pages: 307-313
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/ijmm_00000346
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Abstract

Complement-dependent cytotoxicity is one of the mechanisms by which therapeutic monoclonal antibodies are successful against cancer. Complement is one of the innate immune defence systems, whose activation products and membrane-bound regulators interact with cells of the adaptive immune response. The complement system is currently undergoing a re-appreciation in its role within the immune surveillance of tumour. The majority of human tumours are low immunogenic. Complement may be involved through direct, ‘danger signal’-elicited activation or via infiltration of inflammatory cells, which express complement components. Inflammatory cells may be associated with malignant transformation and tumour regression. The evidence for the effects of complement activation and regulation on tumour progression and expansion will be reviewed using in vivo, in vitro, and patient studies, and conclusions drawn for the implications in therapy and management of tumour patients.

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Copy and paste a formatted citation
Spandidos Publications style
Stover C: Dual role of complement in tumour growth and metastasis (Review). Int J Mol Med 25: 307-313, 2010.
APA
Stover, C. (2010). Dual role of complement in tumour growth and metastasis (Review). International Journal of Molecular Medicine, 25, 307-313. https://doi.org/10.3892/ijmm_00000346
MLA
Stover, C."Dual role of complement in tumour growth and metastasis (Review)". International Journal of Molecular Medicine 25.3 (2010): 307-313.
Chicago
Stover, C."Dual role of complement in tumour growth and metastasis (Review)". International Journal of Molecular Medicine 25, no. 3 (2010): 307-313. https://doi.org/10.3892/ijmm_00000346
Copy and paste a formatted citation
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Spandidos Publications style
Stover C: Dual role of complement in tumour growth and metastasis (Review). Int J Mol Med 25: 307-313, 2010.
APA
Stover, C. (2010). Dual role of complement in tumour growth and metastasis (Review). International Journal of Molecular Medicine, 25, 307-313. https://doi.org/10.3892/ijmm_00000346
MLA
Stover, C."Dual role of complement in tumour growth and metastasis (Review)". International Journal of Molecular Medicine 25.3 (2010): 307-313.
Chicago
Stover, C."Dual role of complement in tumour growth and metastasis (Review)". International Journal of Molecular Medicine 25, no. 3 (2010): 307-313. https://doi.org/10.3892/ijmm_00000346
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