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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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March 2010 Volume 25 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2010 Volume 25 Issue 3

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Article

Specific microRNA expression during chondrogenesis of human mesenchymal stem cells

  • Authors:
    • Jianwei Han
    • Tongtao Yang
    • Jie Gao
    • Jiachang Wu
    • Xiuchun Qiu
    • Qingyu Fan
    • Baoan Ma

  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China
  • Pages: 377-384
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/ijmm_00000355
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Abstract

Mesenchymal stem cells (MSCs) have the capacity to self-renew and differentiate into multiple cell types, but little is known about the precise mechanism of this procedure. Recent studies show that a group of short noncoding RNAs called microRNAs (miRNAs) play a key role in this procedure. However, little work has been done to determine the miRNAs which specifically regulate the differentiation of MSCs. In this study, we cultured human MSCs and chondrogenic differentiation MSCs of 3 donors, and investigated the miRNA expression profiles of MSCs and chondrogenic differentiated MSCs from 2 donors by using miRNA microarrays. We found 5 miRNAs were significantly overexpressed in chondrogenic differentiated MSCs in each sample, and 4 were further confirmed by real-time RT-PCR assay in the sample from the third independent donor. We also predicted the confirmed miRNAs corresponding to putative target genes by online software. The results indicated that the overexpressed miRNAs in chondrogenic differentiated MSCs may play a role in the procedure of MSC chondrogenesis, which offers us guidance for further studies.

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Copy and paste a formatted citation
Spandidos Publications style
Han J, Yang T, Gao J, Wu J, Qiu X, Fan Q and Ma B: Specific microRNA expression during chondrogenesis of human mesenchymal stem cells. Int J Mol Med 25: 377-384, 2010.
APA
Han, J., Yang, T., Gao, J., Wu, J., Qiu, X., Fan, Q., & Ma, B. (2010). Specific microRNA expression during chondrogenesis of human mesenchymal stem cells. International Journal of Molecular Medicine, 25, 377-384. https://doi.org/10.3892/ijmm_00000355
MLA
Han, J., Yang, T., Gao, J., Wu, J., Qiu, X., Fan, Q., Ma, B."Specific microRNA expression during chondrogenesis of human mesenchymal stem cells". International Journal of Molecular Medicine 25.3 (2010): 377-384.
Chicago
Han, J., Yang, T., Gao, J., Wu, J., Qiu, X., Fan, Q., Ma, B."Specific microRNA expression during chondrogenesis of human mesenchymal stem cells". International Journal of Molecular Medicine 25, no. 3 (2010): 377-384. https://doi.org/10.3892/ijmm_00000355
Copy and paste a formatted citation
x
Spandidos Publications style
Han J, Yang T, Gao J, Wu J, Qiu X, Fan Q and Ma B: Specific microRNA expression during chondrogenesis of human mesenchymal stem cells. Int J Mol Med 25: 377-384, 2010.
APA
Han, J., Yang, T., Gao, J., Wu, J., Qiu, X., Fan, Q., & Ma, B. (2010). Specific microRNA expression during chondrogenesis of human mesenchymal stem cells. International Journal of Molecular Medicine, 25, 377-384. https://doi.org/10.3892/ijmm_00000355
MLA
Han, J., Yang, T., Gao, J., Wu, J., Qiu, X., Fan, Q., Ma, B."Specific microRNA expression during chondrogenesis of human mesenchymal stem cells". International Journal of Molecular Medicine 25.3 (2010): 377-384.
Chicago
Han, J., Yang, T., Gao, J., Wu, J., Qiu, X., Fan, Q., Ma, B."Specific microRNA expression during chondrogenesis of human mesenchymal stem cells". International Journal of Molecular Medicine 25, no. 3 (2010): 377-384. https://doi.org/10.3892/ijmm_00000355
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