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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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March 2010 Volume 25 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

The α integrin cytoplasmic motif KXGFFKR is essential for integrin-mediated leukocyte adhesion

  • Authors:
    • Masayoshi Ohkuro
    • Ieharu Hishinuma

  • View Affiliations / Copyright

    Affiliations: Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan. m-okuro@hhc.eisai.co.jp
  • Pages: 439-444
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/ijmm_00000363
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Abstract

During the development of autoimmune and inflammatory diseases, infiltration by multiple leukocyte types is commonly observed at the site of inflammation. These cells are chemotactically recruited via activated integrins expressed on their cell surfaces. However, the detailed mechanism of integrin activation has not been fully elucidated. A specific and highly conserved cytoplasmic amino acid sequence, lysine-x-glycine-phenylalanine-phenylalanine-lysine-arginine (KXGFFKR), is located in the immediate vicinity of the membrane-spanning domain of all α integrins. In this study, we investigated the role of the KXGFFKR motif in the adhesion of leukocytes to human umbilical-vein endothelial cells (HUVEC). Pre-treatment of human neutrophils with a membrane-permeable peptide-linked KVGFFKR decreased cell adhesion to HUVEC induced by a complement activation product, C5a and formyl-methionine-leucine-phenylalanine. Similar inhibitory efficacies of this peptide were observed in T cell adhesion. Our data therefore demonstrate that a highly conserved sequence in the α integrins, KXGFFKR, is pharmacologically essential for integrin activation during leukocyte adhesion by both neutrophils and T cells.

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Copy and paste a formatted citation
Spandidos Publications style
Ohkuro M and Hishinuma I: The α integrin cytoplasmic motif KXGFFKR is essential for integrin-mediated leukocyte adhesion. Int J Mol Med 25: 439-444, 2010.
APA
Ohkuro, M., & Hishinuma, I. (2010). The α integrin cytoplasmic motif KXGFFKR is essential for integrin-mediated leukocyte adhesion. International Journal of Molecular Medicine, 25, 439-444. https://doi.org/10.3892/ijmm_00000363
MLA
Ohkuro, M., Hishinuma, I."The α integrin cytoplasmic motif KXGFFKR is essential for integrin-mediated leukocyte adhesion". International Journal of Molecular Medicine 25.3 (2010): 439-444.
Chicago
Ohkuro, M., Hishinuma, I."The α integrin cytoplasmic motif KXGFFKR is essential for integrin-mediated leukocyte adhesion". International Journal of Molecular Medicine 25, no. 3 (2010): 439-444. https://doi.org/10.3892/ijmm_00000363
Copy and paste a formatted citation
x
Spandidos Publications style
Ohkuro M and Hishinuma I: The α integrin cytoplasmic motif KXGFFKR is essential for integrin-mediated leukocyte adhesion. Int J Mol Med 25: 439-444, 2010.
APA
Ohkuro, M., & Hishinuma, I. (2010). The α integrin cytoplasmic motif KXGFFKR is essential for integrin-mediated leukocyte adhesion. International Journal of Molecular Medicine, 25, 439-444. https://doi.org/10.3892/ijmm_00000363
MLA
Ohkuro, M., Hishinuma, I."The α integrin cytoplasmic motif KXGFFKR is essential for integrin-mediated leukocyte adhesion". International Journal of Molecular Medicine 25.3 (2010): 439-444.
Chicago
Ohkuro, M., Hishinuma, I."The α integrin cytoplasmic motif KXGFFKR is essential for integrin-mediated leukocyte adhesion". International Journal of Molecular Medicine 25, no. 3 (2010): 439-444. https://doi.org/10.3892/ijmm_00000363
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