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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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March 2010 Volume 25 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2010 Volume 25 Issue 3

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Article

Antiviral effect of pyridinium formate, a novel component of coffee extracts

  • Authors:
    • Kazuko Tsujimoto
    • Chiseko Sakuma
    • Misao Uozaki
    • Hisashi Yamasaki
    • Hirotoshi Utsunomiya
    • Kitaro Oka
    • A. Hajime Koyama

  • View Affiliations / Copyright

    Affiliations: Division of Virology, Department of Cellular and Molecular Medicine, Wakayama Medical University Graduate School of Medicine, Wakayama 641-8509, Japan
  • Pages: 459-463
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/ijmm_00000365
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Abstract

N-methyl-pyridinium formate, a novel component of coffee extracts, inhibited the multiplication of both DNA and RNA viruses. In the presence of the compound, the progeny viral yields of both herpes simplex virus type 1 (HSV-1) and poliovirus in HEp-2 cells and those of influenza virus type A in MDCK cells decreased with increasing concentrations of the compound, although the degree of viral sensitivity to this compound differed. In addition, none of these viruses were directly inactivated by the compound at the concentrations tested. Characterization of the mode of action of this compound against HSV-1 multiplication revealed that it inhibits the viral growth primarily at the initial step of virus multiplication, i.e., within 2 h after the onset of multiplication, although the virus multiplication was affected by the compound throughout the multiplication cycle. In addition, this compound showed a significant cytotoxic effect, although the observed antiviral effect was unlikely to be attributed to the cytotoxic effect.

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Copy and paste a formatted citation
Spandidos Publications style
Tsujimoto K, Sakuma C, Uozaki M, Yamasaki H, Utsunomiya H, Oka K and Koyama AH: Antiviral effect of pyridinium formate, a novel component of coffee extracts. Int J Mol Med 25: 459-463, 2010.
APA
Tsujimoto, K., Sakuma, C., Uozaki, M., Yamasaki, H., Utsunomiya, H., Oka, K., & Koyama, A.H. (2010). Antiviral effect of pyridinium formate, a novel component of coffee extracts. International Journal of Molecular Medicine, 25, 459-463. https://doi.org/10.3892/ijmm_00000365
MLA
Tsujimoto, K., Sakuma, C., Uozaki, M., Yamasaki, H., Utsunomiya, H., Oka, K., Koyama, A. H."Antiviral effect of pyridinium formate, a novel component of coffee extracts". International Journal of Molecular Medicine 25.3 (2010): 459-463.
Chicago
Tsujimoto, K., Sakuma, C., Uozaki, M., Yamasaki, H., Utsunomiya, H., Oka, K., Koyama, A. H."Antiviral effect of pyridinium formate, a novel component of coffee extracts". International Journal of Molecular Medicine 25, no. 3 (2010): 459-463. https://doi.org/10.3892/ijmm_00000365
Copy and paste a formatted citation
x
Spandidos Publications style
Tsujimoto K, Sakuma C, Uozaki M, Yamasaki H, Utsunomiya H, Oka K and Koyama AH: Antiviral effect of pyridinium formate, a novel component of coffee extracts. Int J Mol Med 25: 459-463, 2010.
APA
Tsujimoto, K., Sakuma, C., Uozaki, M., Yamasaki, H., Utsunomiya, H., Oka, K., & Koyama, A.H. (2010). Antiviral effect of pyridinium formate, a novel component of coffee extracts. International Journal of Molecular Medicine, 25, 459-463. https://doi.org/10.3892/ijmm_00000365
MLA
Tsujimoto, K., Sakuma, C., Uozaki, M., Yamasaki, H., Utsunomiya, H., Oka, K., Koyama, A. H."Antiviral effect of pyridinium formate, a novel component of coffee extracts". International Journal of Molecular Medicine 25.3 (2010): 459-463.
Chicago
Tsujimoto, K., Sakuma, C., Uozaki, M., Yamasaki, H., Utsunomiya, H., Oka, K., Koyama, A. H."Antiviral effect of pyridinium formate, a novel component of coffee extracts". International Journal of Molecular Medicine 25, no. 3 (2010): 459-463. https://doi.org/10.3892/ijmm_00000365
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