Preventive effects of enzyme-treated rice fiber in a restraint stress-induced irritable bowel syndrome model

  • Authors:
    • Osamu Kanauchi
    • Keiichi Mitsuyama
    • Yutaka Komiyama
    • Minoru Yagi
    • Akira Andoh
    • Michio Sata
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  • Published online on: April 1, 2010     https://doi.org/10.3892/ijmm_00000376
  • Pages: 547-555
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Abstract

Irritable bowel syndrome (IBS) is a common health issue that is characterized by abdominal pain, abnormal bowel movements, altered visceral perception, and abnormal metabolism of 5-hydroxy triptamine (serotonin; 5HT). The use of prebiotics or probiotics treatment for IBS has become increasingly important as an adjunct to pharmaceutical options. The aim of this study was to determine the efficacy of enzyme-treated rice fiber (ERF) on an IBS model. We obtained a new prebiotic from defatted rice bran that was developed as an insoluble dietary fiber through amylase and hemicellulase treatment followed by removal of the soluble fraction. Containing ≈70% hemicellulose, ERF is utilized by lactobacilli and subsequently converted to butyrate using Eubacterium limosum. We employed a restraint stress IBS model which involved the continuous application of stress for 4 h per day for 3 days. Polycarbophil Ca (PC) (500 mg/kg body weight) was used as a positive control and ERF was added to the diet at 4% in diet. During restraint stress, ERF significantly attenuated urgent fecal excretion, colonic mucosal 5HT secretion, and hyperalgesthesia compared with the control. ERF also significantly increased cecal butyrate production as well as total organic acid content. PC was only effective in regard to preventing increases in 5HT levels. Furthermore, there were no significant levels of pro-inflammatory markers CINC-1 and TNF-α among the groups. Although more detailed studies are needed, the ERF prebiotic demonstrated potency in attenuating major symptoms of IBS.

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April 2010
Volume 25 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kanauchi O, Mitsuyama K, Komiyama Y, Yagi M, Andoh A and Sata M: Preventive effects of enzyme-treated rice fiber in a restraint stress-induced irritable bowel syndrome model. Int J Mol Med 25: 547-555, 2010
APA
Kanauchi, O., Mitsuyama, K., Komiyama, Y., Yagi, M., Andoh, A., & Sata, M. (2010). Preventive effects of enzyme-treated rice fiber in a restraint stress-induced irritable bowel syndrome model. International Journal of Molecular Medicine, 25, 547-555. https://doi.org/10.3892/ijmm_00000376
MLA
Kanauchi, O., Mitsuyama, K., Komiyama, Y., Yagi, M., Andoh, A., Sata, M."Preventive effects of enzyme-treated rice fiber in a restraint stress-induced irritable bowel syndrome model". International Journal of Molecular Medicine 25.4 (2010): 547-555.
Chicago
Kanauchi, O., Mitsuyama, K., Komiyama, Y., Yagi, M., Andoh, A., Sata, M."Preventive effects of enzyme-treated rice fiber in a restraint stress-induced irritable bowel syndrome model". International Journal of Molecular Medicine 25, no. 4 (2010): 547-555. https://doi.org/10.3892/ijmm_00000376