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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April 2010 Volume 25 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2010 Volume 25 Issue 4

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Article

Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met

  • Authors:
    • Ke-Min Cai
    • Xue-Li Bao
    • Xu-Hui Kong
    • Wu Jinag
    • Ming-Rong Mao
    • Jiu-Sheng Chu
    • Yong-Jiu Huang
    • Xiao-Jun Zhao

  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology Head and Neck Surgery, Taizhou People's Hospital, Taizhou 225300, Jiangsu, P.R. China. njmucaikemin@126.com
  • Pages: 565-571
    |
    Published online on: April 1, 2010
       https://doi.org/10.3892/ijmm_00000378
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Abstract

MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively modulate gene expression at the post-transcriptional level. A growing number of studies has shown that more and more miRNAs are aberrantly expressed and involved in the pathogenesis of several types of cancers. Here, we report that the down-regulated hsa-miR-34c was also involved in oncogenesis of laryngeal carcinoma. Our studies indicated that hsa-miR-34c functioned as a tumor suppressor which inhibited growth and invasion of human laryngeal carcinoma cells. Furthermore, in our study, an inverse relationship between the expression of hsa-miR-34c and c-Met was identified in 10 paired fresh samples from tumor tissues and adjacent normal tissues. Infection of hsa-miR-34c mediated by lentivirus suppressed the expression of c-Met directly. In addition, introduction of c-Met cDNA lacking 3'-UTR largely abrogated hsa-miR-34c-induced cell growth and invasion inhibition. These findings suggest aberrantly down-regulated hsa-miR-34c is a critical factor that contributes to malignancy in human laryngeal carcinoma by a mechanism involving targeting of c-Met.

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Copy and paste a formatted citation
Spandidos Publications style
Cai K, Bao X, Kong X, Jinag W, Mao M, Chu J, Huang Y and Zhao X: Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met. Int J Mol Med 25: 565-571, 2010.
APA
Cai, K., Bao, X., Kong, X., Jinag, W., Mao, M., Chu, J. ... Zhao, X. (2010). Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met. International Journal of Molecular Medicine, 25, 565-571. https://doi.org/10.3892/ijmm_00000378
MLA
Cai, K., Bao, X., Kong, X., Jinag, W., Mao, M., Chu, J., Huang, Y., Zhao, X."Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met". International Journal of Molecular Medicine 25.4 (2010): 565-571.
Chicago
Cai, K., Bao, X., Kong, X., Jinag, W., Mao, M., Chu, J., Huang, Y., Zhao, X."Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met". International Journal of Molecular Medicine 25, no. 4 (2010): 565-571. https://doi.org/10.3892/ijmm_00000378
Copy and paste a formatted citation
x
Spandidos Publications style
Cai K, Bao X, Kong X, Jinag W, Mao M, Chu J, Huang Y and Zhao X: Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met. Int J Mol Med 25: 565-571, 2010.
APA
Cai, K., Bao, X., Kong, X., Jinag, W., Mao, M., Chu, J. ... Zhao, X. (2010). Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met. International Journal of Molecular Medicine, 25, 565-571. https://doi.org/10.3892/ijmm_00000378
MLA
Cai, K., Bao, X., Kong, X., Jinag, W., Mao, M., Chu, J., Huang, Y., Zhao, X."Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met". International Journal of Molecular Medicine 25.4 (2010): 565-571.
Chicago
Cai, K., Bao, X., Kong, X., Jinag, W., Mao, M., Chu, J., Huang, Y., Zhao, X."Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met". International Journal of Molecular Medicine 25, no. 4 (2010): 565-571. https://doi.org/10.3892/ijmm_00000378
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