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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2010 Volume 25 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Effect of ribavirin and interferon β on miRNA profile in the hepatitis C virus subgenomic replicon-bearing Huh7 cells

  • Authors:
    • Bang-Dong Gong
    • Qing Xie
    • Xiao-Gang Xiang
    • Lin Wang
    • Gang-De Zhao
    • Fang-Mei An
    • Hui Wang
    • Lan-Yi Lin
    • Hong Yu
    • Shi-San Bao

  • View Affiliations / Copyright

    Affiliations: Department of Infectious Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China
  • Pages: 853-859
    |
    Published online on: June 1, 2010
       https://doi.org/10.3892/ijmm_00000414
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Abstract

Hepatitis C virus (HCV) infection is still a major global health issue despite decades of research. The liver-specific microRNA-122 (miR-122) can stimulate HCV replication/translation in vitro, indicating that miR-122 contributes to pathogenesis of HCV. However, it remains controversial whether interferon (IFN) inhibits HCV via modulating miR-122 expression. The underlying mechanism of ribavirin (RBV) in enhancing IFN treatment for HCV patients has yet to be explored. We investigated the relationship between miR-122 expression and anti-HCV activity of IFN β in combination with RBV in vitro, due to difficulty accessing an HCV animal model. Upregulation of ISG54 mRNA or cytostatic effect was detected in Huh7 and HCV replicon cell lines in response to IFN β or RBV stimulation, respectively. It was found that IFN β and/or RBV suppressed miR-122 expression marginally, with a synergetic anti-HCV effect between IFN β and RBV. Marginal modification of other miRNAs was also observed in these cell lines, using miRNA array following IFN β and RBV treatment. Taken together, our data suggest that miRNAs are not crucial in anti-HCV action, following IFN β and/or RBV stimulation in vitro.

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Copy and paste a formatted citation
Spandidos Publications style
Gong B, Xie Q, Xiang X, Wang L, Zhao G, An F, Wang H, Lin L, Yu H, Bao S, Bao S, et al: Effect of ribavirin and interferon β on miRNA profile in the hepatitis C virus subgenomic replicon-bearing Huh7 cells. Int J Mol Med 25: 853-859, 2010.
APA
Gong, B., Xie, Q., Xiang, X., Wang, L., Zhao, G., An, F. ... Bao, S. (2010). Effect of ribavirin and interferon β on miRNA profile in the hepatitis C virus subgenomic replicon-bearing Huh7 cells. International Journal of Molecular Medicine, 25, 853-859. https://doi.org/10.3892/ijmm_00000414
MLA
Gong, B., Xie, Q., Xiang, X., Wang, L., Zhao, G., An, F., Wang, H., Lin, L., Yu, H., Bao, S."Effect of ribavirin and interferon β on miRNA profile in the hepatitis C virus subgenomic replicon-bearing Huh7 cells". International Journal of Molecular Medicine 25.6 (2010): 853-859.
Chicago
Gong, B., Xie, Q., Xiang, X., Wang, L., Zhao, G., An, F., Wang, H., Lin, L., Yu, H., Bao, S."Effect of ribavirin and interferon β on miRNA profile in the hepatitis C virus subgenomic replicon-bearing Huh7 cells". International Journal of Molecular Medicine 25, no. 6 (2010): 853-859. https://doi.org/10.3892/ijmm_00000414
Copy and paste a formatted citation
x
Spandidos Publications style
Gong B, Xie Q, Xiang X, Wang L, Zhao G, An F, Wang H, Lin L, Yu H, Bao S, Bao S, et al: Effect of ribavirin and interferon β on miRNA profile in the hepatitis C virus subgenomic replicon-bearing Huh7 cells. Int J Mol Med 25: 853-859, 2010.
APA
Gong, B., Xie, Q., Xiang, X., Wang, L., Zhao, G., An, F. ... Bao, S. (2010). Effect of ribavirin and interferon β on miRNA profile in the hepatitis C virus subgenomic replicon-bearing Huh7 cells. International Journal of Molecular Medicine, 25, 853-859. https://doi.org/10.3892/ijmm_00000414
MLA
Gong, B., Xie, Q., Xiang, X., Wang, L., Zhao, G., An, F., Wang, H., Lin, L., Yu, H., Bao, S."Effect of ribavirin and interferon β on miRNA profile in the hepatitis C virus subgenomic replicon-bearing Huh7 cells". International Journal of Molecular Medicine 25.6 (2010): 853-859.
Chicago
Gong, B., Xie, Q., Xiang, X., Wang, L., Zhao, G., An, F., Wang, H., Lin, L., Yu, H., Bao, S."Effect of ribavirin and interferon β on miRNA profile in the hepatitis C virus subgenomic replicon-bearing Huh7 cells". International Journal of Molecular Medicine 25, no. 6 (2010): 853-859. https://doi.org/10.3892/ijmm_00000414
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