Open Access

The expressions of carbonic anhydrase 9 and vascular endothelial growth factor in astrocytic tumors predict a poor prognosis

  • Authors:
    • Heon Yoo
    • Seil Sohn
    • Byung Ho Nam
    • Hye Sook Min
    • Eugene Jung
    • Sang Hoon Shin
    • Ho-Shin Gwak
    • Seung Hoon Lee
  • View Affiliations

  • Published online on: July 1, 2010     https://doi.org/10.3892/ijmm_00000427
  • Pages: 3-9
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Abstract

Hypoxia in the tumor microenvironment triggers a variety of genetic and adoptive responses that regulate tumor growth. Tumor hypoxia is often associated with a malignant phenotype, resistance to therapy, and poor survival. The objectives of this study were to evaluate the expressions of carbonic anhydrase 9 (CA9) and vascular endothelial growth factor (VEGF) in astrocytic gliomas and to relate patterns of expression with prognosis, that is with histological grade and survival. We investigated 78 World Health Organization (WHO) grade II, III, and IV astrocytic gliomas. CA9 expression was examined in paraffin-embedded sections by immunohistochemistry. Fourteen tumors were grade II, 30 were grade III, and 34 were grade IV. It was found that CA9 expression was significantly associated with a higher-grade histology (p<0.001). There were 3 CA9 positive tumors in grade II (21.4%), 10 in grade III (33.3%), and 27 in grade IV (79.4%). For all tumors and WHO grade II, overall survival was found to be significantly dependent on CA9 expression (p=0.004, p=0.01). Furthermore, VEGF expression was found to be significantly related to tumor grade (p=0.02) and tended to be related to overall survival (p=0.1). However, no relation was found between the expression of CA9 and VEGF (p=0.17). Nevertheless, the expressions of CA9 and VEGF were found to be associated with tumor grade and possibly with survival. Further studies on a larger patient population are needed to determine the correlation between the expressions of CA9, and VEGF in astrocytic gliomas and clinical outcome.

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July 2010
Volume 26 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yoo H, Sohn S, Nam BH, Min HS, Jung E, Shin SH, Gwak H and Lee SH: The expressions of carbonic anhydrase 9 and vascular endothelial growth factor in astrocytic tumors predict a poor prognosis . Int J Mol Med 26: 3-9, 2010.
APA
Yoo, H., Sohn, S., Nam, B.H., Min, H.S., Jung, E., Shin, S.H. ... Lee, S.H. (2010). The expressions of carbonic anhydrase 9 and vascular endothelial growth factor in astrocytic tumors predict a poor prognosis . International Journal of Molecular Medicine, 26, 3-9. https://doi.org/10.3892/ijmm_00000427
MLA
Yoo, H., Sohn, S., Nam, B. H., Min, H. S., Jung, E., Shin, S. H., Gwak, H., Lee, S. H."The expressions of carbonic anhydrase 9 and vascular endothelial growth factor in astrocytic tumors predict a poor prognosis ". International Journal of Molecular Medicine 26.1 (2010): 3-9.
Chicago
Yoo, H., Sohn, S., Nam, B. H., Min, H. S., Jung, E., Shin, S. H., Gwak, H., Lee, S. H."The expressions of carbonic anhydrase 9 and vascular endothelial growth factor in astrocytic tumors predict a poor prognosis ". International Journal of Molecular Medicine 26, no. 1 (2010): 3-9. https://doi.org/10.3892/ijmm_00000427