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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2010 Volume 26 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2010 Volume 26 Issue 1

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Article

Knockdown of the Dickkopf 3 gene induces apoptosis in a lung adenocarcinoma

  • Authors:
    • Il Lae Jung
    • Hyo Jin Kang
    • Kug Chan Kim
    • In Gyu Kim

  • View Affiliations / Copyright

    Affiliations: Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, Daejeon 305-600, Korea
  • Pages: 33-38
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/ijmm_00000431
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Abstract

The expression of the Wnt-antagonist Dickkopf gene (DKK) is downregulated in several types of tumors as a consequence of epigenetic DNA modification; four DKK members, DKK1, DKK2, DKK3, and DKK4, have been identified. In this study, we investigated another function of DKK3 in non-small cell lung cancer H460 cells, in which DKK3 was hypermethylated (44%) but still expressed, by interfering with DKK3 expression using DKK3-silencing RNA (SiRNA). We found that knockdown of DKK3 expression by DKK3 SiRNA transfection led to the detachment of H460 cells from the bottom of the culture plate and caused apoptosis. The expression of cyclin-dependent kinases D1 and E were increased by DKK3 knockdown, indicating that cells with blocked DKK3 expression entered the apoptotic pathway. We also found that the intracellular level of reactive oxygen species was higher in cells with blocked DKK3 expression than in normal H460 cells, and levels of p53, p21, and Bax were also increased by the gene knockdown. These results indicate that DKK3 acts as an antiapoptotic molecule by decreasing the intracellular level of reactive oxygen species.

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Copy and paste a formatted citation
Spandidos Publications style
Jung IL, Kang HJ, Kim KC and Kim IG: Knockdown of the Dickkopf 3 gene induces apoptosis in a lung adenocarcinoma . Int J Mol Med 26: 33-38, 2010.
APA
Jung, I.L., Kang, H.J., Kim, K.C., & Kim, I.G. (2010). Knockdown of the Dickkopf 3 gene induces apoptosis in a lung adenocarcinoma . International Journal of Molecular Medicine, 26, 33-38. https://doi.org/10.3892/ijmm_00000431
MLA
Jung, I. L., Kang, H. J., Kim, K. C., Kim, I. G."Knockdown of the Dickkopf 3 gene induces apoptosis in a lung adenocarcinoma ". International Journal of Molecular Medicine 26.1 (2010): 33-38.
Chicago
Jung, I. L., Kang, H. J., Kim, K. C., Kim, I. G."Knockdown of the Dickkopf 3 gene induces apoptosis in a lung adenocarcinoma ". International Journal of Molecular Medicine 26, no. 1 (2010): 33-38. https://doi.org/10.3892/ijmm_00000431
Copy and paste a formatted citation
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Spandidos Publications style
Jung IL, Kang HJ, Kim KC and Kim IG: Knockdown of the Dickkopf 3 gene induces apoptosis in a lung adenocarcinoma . Int J Mol Med 26: 33-38, 2010.
APA
Jung, I.L., Kang, H.J., Kim, K.C., & Kim, I.G. (2010). Knockdown of the Dickkopf 3 gene induces apoptosis in a lung adenocarcinoma . International Journal of Molecular Medicine, 26, 33-38. https://doi.org/10.3892/ijmm_00000431
MLA
Jung, I. L., Kang, H. J., Kim, K. C., Kim, I. G."Knockdown of the Dickkopf 3 gene induces apoptosis in a lung adenocarcinoma ". International Journal of Molecular Medicine 26.1 (2010): 33-38.
Chicago
Jung, I. L., Kang, H. J., Kim, K. C., Kim, I. G."Knockdown of the Dickkopf 3 gene induces apoptosis in a lung adenocarcinoma ". International Journal of Molecular Medicine 26, no. 1 (2010): 33-38. https://doi.org/10.3892/ijmm_00000431
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