Permanent up-regulation of regulatory T-lymphocytes in patients with head and neck cancer

  • Authors:
    • Anne K. Schott
    • Ralph Pries
    • Barbara Wollenberg
  • View Affiliations

  • Published online on: July 1, 2010     https://doi.org/10.3892/ijmm_00000436
  • Pages: 67-75
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Abstract

Various immune functions of different types of immune cells are strongly impaired in patients with head and neck squamous cell carcinoma (HNSCC). Regulatory T-lymphocyte cells (Tregs) have been suggested to be involved in the immunomodulation of immune responses and contribute to HNSCC progression and immune escape. ‘Naturally’ occurring CD4+CD25+ Tregs represent a small fraction within the different subsets of regulatory T cells, which are known to inhibit numerous immune functions of different types of immune cells. In this study, the cellular ratio of CD4+CD25high Tregs to the entire population of CD4+ T-lymphocytes was analyzed with respect to different stages of tumor progression and disease. Our data indicate a significantly high increased abundance of CD4+CD25highCD127low Tregs in the peripheral blood of patients with HNSCC, which in addition show modulated expression levels of various functional proteins. Surprisingly, increased Treg levels were found even in patients with no active disease several years after tumor resection, with no significant correlation to the individual tumor stage. Additionally, increased levels of chemokine CCL22, which mediates migration of Tregs to the tumor, and upregulation of the corresponding receptor protein CCR4 were observed in HNSCC. Our data strongly suggest that HNSCC leads to a permanent shift of Treg levels with hardly recognizable recovery rates.

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July 2010
Volume 26 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Schott AK, Pries R and Wollenberg B: Permanent up-regulation of regulatory T-lymphocytes in patients with head and neck cancer . Int J Mol Med 26: 67-75, 2010.
APA
Schott, A.K., Pries, R., & Wollenberg, B. (2010). Permanent up-regulation of regulatory T-lymphocytes in patients with head and neck cancer . International Journal of Molecular Medicine, 26, 67-75. https://doi.org/10.3892/ijmm_00000436
MLA
Schott, A. K., Pries, R., Wollenberg, B."Permanent up-regulation of regulatory T-lymphocytes in patients with head and neck cancer ". International Journal of Molecular Medicine 26.1 (2010): 67-75.
Chicago
Schott, A. K., Pries, R., Wollenberg, B."Permanent up-regulation of regulatory T-lymphocytes in patients with head and neck cancer ". International Journal of Molecular Medicine 26, no. 1 (2010): 67-75. https://doi.org/10.3892/ijmm_00000436