Anti-asthmatic effect of Sanguisorba officinalis L. and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model

  • Authors:
    • Nam-Hun Lee
    • Mee-Young Lee
    • Jin-Ah Lee
    • Da-Young Jung
    • Chang-Seob Seo
    • Jung-Hoon Kim
    • Hyeun-Kyoo Shin
  • View Affiliations

  • Published online on: August 1, 2010     https://doi.org/10.3892/ijmm_00000453
  • Pages: 201-208
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Abstract

Sanguisorba officinalis L. is known to have anti-inflammatory properties. However, the potential effects of S. officinalis against asthma have not been reported. In the present study, we investigated the protective effects and underlying mechanisms of S. officinalis in a murine ovalbumin (OVA)-induced asthma model. Mice were sensitized and challenged by OVA inhalation to induce airway inflammation and remodeling. S. officinalis ethanolic extract (SOEE) markedly decreased the number of infiltrated inflammatory cells, together with a reduction in the levels of T-helper type 2 cytokines and immunoglobulin E levels. Histopathological studies showed that inflammatory cell infiltration and mucus hypersecretion were inhibited by SOEE. In addition, OVA-induced increases in reactive oxygen species were attenuated by SOEE. All these effects were correlated with heme oxygenase-1 (HO-1) induction by SOEE. These results indicate that SOEE has therapeutic potential against bronchial asthma associated with allergic diseases that is due, at least in part, to HO-1 upregulation.

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August 2010
Volume 26 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Lee, N., Lee, M., Lee, J., Jung, D., Seo, C., Kim, J., & Shin, H. (2010). Anti-asthmatic effect of Sanguisorba officinalis L. and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model. International Journal of Molecular Medicine, 26, 201-208. https://doi.org/10.3892/ijmm_00000453
MLA
Lee, N., Lee, M., Lee, J., Jung, D., Seo, C., Kim, J., Shin, H."Anti-asthmatic effect of Sanguisorba officinalis L. and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model". International Journal of Molecular Medicine 26.2 (2010): 201-208.
Chicago
Lee, N., Lee, M., Lee, J., Jung, D., Seo, C., Kim, J., Shin, H."Anti-asthmatic effect of Sanguisorba officinalis L. and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model". International Journal of Molecular Medicine 26, no. 2 (2010): 201-208. https://doi.org/10.3892/ijmm_00000453