Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation

Beppu,Tetsuya; Sugimoto,Kazushi; Shiraki,Katsuya; Tameda,Masahiko; Kusagawa,Satoko; Nojiri,Keiichiro; Tanaka,Junichiro; Yamamoto,Norihiko; Takei,Yoshiyuki; Takaki,Haruyuki; Uraki,Junji; Nakatsuka,Atsuhiro; Yamakado,Koichiro; Takeda,Kan

doi:10.3892/ijmm_00000482

September 2010 Volume 26 Issue 3

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September 2010 Volume 26 Issue 3

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Article

Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation

Authors:
- Tetsuya Beppu
- Kazushi Sugimoto
- Katsuya Shiraki
- Masahiko Tameda
- Satoko Kusagawa
- Keiichiro Nojiri
- Junichiro Tanaka
- Norihiko Yamamoto
- Yoshiyuki Takei
- Haruyuki Takaki
- Junji Uraki
- Atsuhiro Nakatsuka
- Koichiro Yamakado
- Kan Takeda
View Affiliations / Copyright

Affiliations: Department of Gastroenterology, Mie University School of Medicine, Tsu, Mie 514-8507, Japan
Pages: 425-433
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Published online on: September 1, 2010

https://doi.org/10.3892/ijmm_00000482
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Abstract

The aim of this study was to elucidate the importance of three tumor markers, α-fetoprotein (AFP), Lens culinaris agglutinin A-reactive fraction of AFP (AFP-L3), and des-γ-carboxy prothrombin (DCP), for detecting and predicting the recurrence of hepatocellular carcinomas (HCCs). A total of 108 patients with initial non-advanced HCC who underwent curative radiofrequency ablation (RFA) in our hospital were enrolled in this study. The effectiveness of the three tumor markers for detecting recurrence and recurrence-free survival was analyzed. Positivity of these three makers was not markedly increased at the first or second recurrence. In addition, there was no significant correlation between the initial and recurrent levels of each tumor marker. The tumor marker that was positive at the time of initial HCC was not necessarily positive at recurrence. The tumor marker levels at recurrence were not correlated with pre-ablation levels. No significant correlation was found in the tumor marker values between pre-ablation and the time of recurrence. On multivariate analysis, high AFP-L3 levels (≥10%) were significantly predictive of recurrence-free survival. All three tumor markers should be routinely measured to detect recurrence during follow-up after RFA. Especially high AFP-L3 levels should be followed closely.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation

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Abstract

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